{"id":"W2072929674","doi":"10.1016/j.matbio.2010.10.007","title":"MMPs are less efficient than ADAMTS5 in cleaving aggrecan core protein","year":2010,"lang":"en","type":"article","venue":"Matrix Biology","topic":"Signaling Pathways in Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":74,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University; Shriners Hospitals for Children - Canada","funders":"National Institute of Arthritis and Musculoskeletal and Skin Diseases; Canadian Institutes of Health Research; National Institutes of Health; Wellcome Trust","keywords":"Aggrecan; Matrix metalloproteinase; Chemistry; Aggrecanase; Core protein; Cell biology; Biochemistry; Medicine; Biology; Osteoarthritis; Pathology; Articular cartilage","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001012577,0.0003836292,0.000639925,0.0007434354,0.0002134589,0.001076592,0.0003424485,0.0004285002,0.002808223],"category_scores_gemma":[0.001205595,0.0003105711,0.0006133511,0.0003477618,0.0002891253,0.0005825307,0.0002911896,0.000544247,0.001066463],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005175398,"about_ca_system_score_gemma":0.0003380394,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001455055,"about_ca_topic_score_gemma":0.0009798459,"domain_scores_codex":[0.9987059,0.0003012716,0.0002149671,0.0001626578,0.0003865915,0.0002286258],"domain_scores_gemma":[0.9991622,0.0001867852,0.0001539981,0.0001431381,0.0002267844,0.0001271272],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000473587,0.00005404121,0.003492795,0.0001340474,0.0000572959,0.0001494846,0.00004694631,0.0001031636,0.988184,0.0002301414,0.0001841366,0.006890357],"study_design_scores_gemma":[0.00001772051,0.0003645726,0.01436728,0.000009401102,0.00004364322,0.001428838,0.00006719115,0.0004498627,0.9795259,0.00008813743,0.003630384,0.000007077393],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.990546,0.004360033,0.003114325,0.0001308667,0.00005648483,0.00002544703,0.0004390095,0.00008463526,0.001243237],"genre_scores_gemma":[0.9896998,0.001083723,0.003042907,0.00007089907,0.00002141899,0.00001982342,0.001677397,0.0000432369,0.004340646],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002808223,"threshold_uncertainty_score":0.009394407,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01693210080014667,"score_gpt":0.2845931155551137,"score_spread":0.267661014754967,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}