{"id":"W2072974503","doi":"10.1016/j.canlet.2008.09.012","title":"Telomerase inhibition induces acute ATM-dependent growth arrest in human astrocytomas","year":2008,"lang":"en","type":"article","venue":"Cancer Letters","topic":"Telomeres, Telomerase, and Senescence","field":"Medicine","cited_by":21,"is_retracted":false,"has_abstract":false,"ca_institutions":"SickKids Foundation; Hospital for Sick Children; University of Toronto","funders":"","keywords":"Telomerase; Telomere; Telomerase reverse transcriptase; Cancer research; Astrocytoma; Protein subunit; Anaplastic astrocytoma; Cell cycle checkpoint; DNA damage; Cell growth; Biology; Cell cycle; Medicine; Glioma; Cell; DNA; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001018933,0.0002823286,0.000413939,0.0003153482,0.000180248,0.00002075526,0.0001235891,0.000112387,0.0001751028],"category_scores_gemma":[0.00002275383,0.0002705315,0.0001019675,0.0004192302,0.0002271745,0.0002471021,0.00004290681,0.0004541388,0.0000595442],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004123919,"about_ca_system_score_gemma":0.0001382591,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008081485,"about_ca_topic_score_gemma":0.0002180276,"domain_scores_codex":[0.9980815,0.00005350805,0.0003980842,0.0005044491,0.0004477646,0.0005146679],"domain_scores_gemma":[0.9992579,0.00002721092,0.0001199955,0.0003042837,0.00006451972,0.0002261332],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002098254,0.0001659522,0.130699,0.00008630519,0.00008659065,0.003298734,0.00121272,0.0000144423,0.8544164,0.00003834728,0.008650579,0.001121089],"study_design_scores_gemma":[0.005374864,0.0002474365,0.4937392,0.0005283171,0.0001302382,0.0004344388,0.0001941274,0.00001448233,0.4969209,0.000024352,0.001735582,0.0006560399],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9923915,0.0003204656,0.00005139727,0.005949366,0.0004271553,0.0003678768,0.00002464304,0.0001205296,0.0003470557],"genre_scores_gemma":[0.9905841,0.0003131762,0.0001679437,0.007837779,0.0006010692,0.0001071061,0.00006387138,0.00004242305,0.0002824888],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3630401,"threshold_uncertainty_score":0.9999747,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02471248875712463,"score_gpt":0.2805603645905728,"score_spread":0.2558478758334482,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}