{"id":"W2072982267","doi":"10.1016/j.biotechadv.2004.06.001","title":"ORC-associated replication factors as biomarkers for cancer","year":2004,"lang":"en","type":"review","venue":"Biotechnology Advances","topic":"DNA Repair Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":65,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Waterloo","funders":"","keywords":"Minichromosome maintenance; DNA replication; Biology; Replication (statistics); Cancer; Biomarker; Computational biology; Budding yeast; Cancer research; Origin recognition complex; Genetics; Bioinformatics; Yeast; DNA; Cell biology; Origin of replication; Eukaryotic DNA replication; Saccharomyces cerevisiae; Virology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity"],"consensus_categories":[],"category_scores_codex":[0.0001897004,0.0004991121,0.0008736385,0.0001881742,0.0001322526,0.0000145394,0.0006346866,0.002229963,0.00001503609],"category_scores_gemma":[0.0008642199,0.0004316324,0.000470284,0.0003154652,0.0002056597,0.00000620958,0.0001547398,0.0002267264,0.00001535669],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002005442,"about_ca_system_score_gemma":0.0004470195,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002718892,"about_ca_topic_score_gemma":0.00007646329,"domain_scores_codex":[0.9977519,0.00005443564,0.0004638234,0.001181196,0.0001095732,0.0004390969],"domain_scores_gemma":[0.9980956,0.00004528568,0.0006371225,0.001076286,0.00008485009,0.00006089656],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00001875827,0.0000689043,0.000003884169,0.002244244,0.0005911575,0.000001621619,0.000003632924,0.000001631132,0.005603502,0.00100009,0.0003469928,0.9901156],"study_design_scores_gemma":[0.0002236616,0.0002965275,5.026714e-7,0.001442898,0.0003018351,0.000009850804,0.00001722114,4.940178e-7,0.05959547,0.0007714175,0.9368951,0.0004449617],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0002777848,0.9963158,0.0007123651,0.0001385748,0.0005506028,0.001385931,0.0003283904,0.0002231546,0.00006744129],"genre_scores_gemma":[0.00009578436,0.9952592,0.001313847,0.00004653531,0.00008439475,0.001040085,0.001460568,0.00009542235,0.0006042168],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9896706,"threshold_uncertainty_score":0.9998136,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02315113374540064,"score_gpt":0.3464353379373256,"score_spread":0.323284204191925,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}