{"id":"W2072994787","doi":"10.1074/jbc.m113.496117","title":"Identification of Novel Cholesterol-binding Regions in Kir2 Channels","year":2013,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Ion channel regulation and function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":106,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"National Heart, Lung, and Blood Institute; Canadian Institutes of Health Research","keywords":"Transmembrane domain; Potassium channel; Ion channel; Cholesterol; Inward-rectifier potassium ion channel; Gating; Transmembrane protein; Chemistry; Cell biology; Biophysics; Membrane potential; Biochemistry; Cyclic nucleotide-binding domain; Biology; Membrane; Receptor; Peptide sequence; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003592438,0.0005604017,0.0008714932,0.0004073744,0.0005780898,0.000683835,0.0005878578,0.0008620573,0.0008929214],"category_scores_gemma":[0.000745377,0.0002682948,0.0008885772,0.0003154237,0.0003150696,0.0005072448,0.0004143047,0.0005126648,0.0002349906],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005458629,"about_ca_system_score_gemma":0.0009979174,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002491114,"about_ca_topic_score_gemma":0.002689172,"domain_scores_codex":[0.9998399,0.00002684931,0.00001203133,0.00004142164,0.00004905763,0.00003065673],"domain_scores_gemma":[0.9997638,0.00007447958,0.0000624967,0.00001628558,0.00004670949,0.00003628965],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"simulation_or_modeling","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002098726,0.0007259745,0.06316382,0.001367181,0.0004077005,0.005279766,0.0003819908,0.5024995,0.3628476,0.01690554,0.002116245,0.04220591],"study_design_scores_gemma":[0.0002004692,0.0001513262,0.007056446,0.00004042283,0.0001447367,0.000437363,0.0000979187,0.9609168,0.02659076,0.00315636,0.001159244,0.00004815076],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9607085,0.0006398486,0.03579063,0.0001644043,0.00004228626,0.00008520223,0.0004285357,0.0004810686,0.001659611],"genre_scores_gemma":[0.9769362,0.0001807068,0.0219332,0.00007086474,0.00001038491,0.00005460519,0.0005960101,0.00002889919,0.0001892805],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002491114,"threshold_uncertainty_score":0.004953206,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0354618750536276,"score_gpt":0.2689567984633638,"score_spread":0.2334949234097362,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}