{"id":"W20730394","doi":"10.1055/s-2003-45138","title":"Implications of the Neuroprotective Effects of Lithium for the Treatment of Bipolar and Neurodegenerative Disorders","year":2003,"lang":"en","type":"review","venue":"Pharmacopsychiatry","topic":"Bipolar Disorder and Treatment","field":"Medicine","cited_by":108,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Dalhousie University","funders":"","keywords":"Neuroprotection; Lithium (medication); GSK-3; Excitotoxicity; Neurogenesis; Treatment of bipolar disorder; Neuroscience; Glutamate receptor; Bipolar disorder; Kinase; Pharmacology; Medicine; Psychology; Internal medicine; Biology; Mania; Cell biology; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005154044,0.0007884619,0.001259899,0.002225535,0.0003287748,0.0007555572,0.0006525805,0.00102659,0.004716388],"category_scores_gemma":[0.0007176548,0.0001583124,0.0003622045,0.003069217,0.000460598,0.001047291,0.000324598,0.001018865,0.001928102],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005876385,"about_ca_system_score_gemma":0.001016897,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002017579,"about_ca_topic_score_gemma":0.005877543,"domain_scores_codex":[0.9998292,0.00004622816,0.00003153605,0.00002299337,0.00005947945,0.00001051509],"domain_scores_gemma":[0.9996579,0.0001649087,0.00004952011,0.00001011622,0.00008683372,0.00003061645],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0000939301,0.00007016199,0.0003105382,0.01108898,0.00008484656,0.0004694387,0.00008748563,0.0002699771,0.001240928,0.002347067,0.02919089,0.9547457],"study_design_scores_gemma":[0.00004543459,0.0001493461,0.00264031,0.005461967,0.000150159,0.003474434,0.0001714133,0.0001016524,0.0003327623,0.002728489,0.9847249,0.00001906151],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001092228,0.9982085,0.0000427993,0.0002820576,0.000121002,0.000002412704,0.000007479633,0.000003888729,0.001222659],"genre_scores_gemma":[0.0009020717,0.9977586,0.000179801,0.0002574062,0.0001391619,0.000005500545,0.00001677201,9.203578e-7,0.0007397566],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.004716388,"threshold_uncertainty_score":0.01577795,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02653410877744456,"score_gpt":0.3456024581462271,"score_spread":0.3190683493687825,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}