{"id":"W2073044683","doi":"10.4161/hv.5.2.7210","title":"BCG Vaccines: Their mechanisms of attenuation and impact on safety and protective efficacy","year":2009,"lang":"en","type":"review","venue":"Human Vaccines","topic":"Tuberculosis Research and Epidemiology","field":"Medicine","cited_by":141,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Canadian Institutes of Health Research; National Natural Science Foundation of China","keywords":"Virulence; Mycobacterium bovis; Mycobacterium tuberculosis; BCG vaccine; Tuberculosis vaccines; Tuberculosis; Tuberculin; Attenuated vaccine; Biology; Virology; Immunization; Immunology; Vaccination; Microbiology; Medicine; Immune system; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007547871,0.0006177618,0.001311962,0.0013129,0.0001669817,0.0006979672,0.0006661681,0.000963412,0.00192029],"category_scores_gemma":[0.0008773332,0.0002382221,0.000314716,0.001301311,0.0005095872,0.001045062,0.0003984316,0.001078976,0.001376924],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006047457,"about_ca_system_score_gemma":0.000737294,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006889238,"about_ca_topic_score_gemma":0.0008161985,"domain_scores_codex":[0.9997784,0.00005609884,0.00002590566,0.00003346705,0.00008554876,0.00002051102],"domain_scores_gemma":[0.9996989,0.0001523998,0.00004651789,0.00001063542,0.00006788204,0.00002372243],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001383302,0.00006663668,0.0002401611,0.01150772,0.00005878507,0.0001318195,0.00005532673,0.0003448705,0.004412506,0.003750436,0.009063819,0.9702296],"study_design_scores_gemma":[0.00004840177,0.0003371519,0.002443515,0.003712702,0.0001343235,0.001593164,0.00008856788,0.0001394743,0.002827302,0.003023227,0.9856258,0.00002632807],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0002405616,0.99883,0.00009027583,0.0001686234,0.00006736992,0.000002716849,0.000009023945,0.000003672242,0.0005877723],"genre_scores_gemma":[0.001152464,0.9982003,0.0001347253,0.00008572195,0.0000745018,0.00000478713,0.00001242555,7.174813e-7,0.0003343729],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.00192029,"threshold_uncertainty_score":0.00642401,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07193749844206884,"score_gpt":0.4067609517440112,"score_spread":0.3348234533019423,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}