{"id":"W2073044683","doi":"10.4161/hv.5.2.7210","title":"BCG Vaccines: Their mechanisms of attenuation and impact on safety and protective efficacy","year":2009,"lang":"en","type":"review","venue":"Human Vaccines","topic":"Tuberculosis Research and Epidemiology","field":"Medicine","cited_by":141,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Canadian Institutes of Health Research; National Natural Science Foundation of China","keywords":"Virulence; Mycobacterium bovis; Mycobacterium tuberculosis; BCG vaccine; Tuberculosis vaccines; Tuberculosis; Tuberculin; Attenuated vaccine; Biology; Virology; Immunization; Immunology; Vaccination; Microbiology; Medicine; Immune system; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0007475646,0.0005306036,0.002697941,0.0004648005,0.000129509,0.00001587771,0.0001234339,0.0003772605,0.0001045796],"category_scores_gemma":[0.0006734391,0.0002997066,0.0003589104,0.0002403472,0.00003486685,0.00005836947,0.00007643717,0.0005498187,0.00001187872],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001106407,"about_ca_system_score_gemma":0.0001101929,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007719838,"about_ca_topic_score_gemma":0.00001907688,"domain_scores_codex":[0.9976784,0.0004198962,0.000765851,0.0005724476,0.0001795127,0.0003838786],"domain_scores_gemma":[0.9981051,0.0006470745,0.0004059918,0.000463174,0.0001527817,0.0002258469],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0004194756,0.000170274,0.0001167318,0.006123851,0.0004974317,0.0000111602,0.00008736327,8.489038e-7,0.00007585792,0.000770767,0.0007029655,0.9910233],"study_design_scores_gemma":[0.01572769,0.03132204,0.3499225,0.08351453,0.005985622,0.001972817,0.0002676971,0.0001622396,0.0002241161,0.01792299,0.49015,0.002827709],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.004426654,0.9912718,0.0000922516,0.0004156781,0.00003485159,0.003155239,0.00005874731,0.00005682921,0.0004879648],"genre_scores_gemma":[0.006744075,0.9923506,0.00007941185,0.0001035745,0.0002705088,0.00006862934,0.0001925833,0.0000525965,0.0001380348],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9881955,"threshold_uncertainty_score":0.9999455,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07193749844206884,"score_gpt":0.4067609517440112,"score_spread":0.3348234533019423,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}