{"id":"W2073059894","doi":"10.1073/pnas.202296999","title":"Lipoxin A 4 and aspirin-triggered 15-epi-lipoxin A 4 inhibit peroxynitrite formation, NF-κB and AP-1 activation, and IL-8 gene expression in human leukocytes","year":2002,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Peroxisome Proliferator-Activated Receptors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":250,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Hôpital Maisonneuve-Rosemont","funders":"National Institute of Dental and Craniofacial Research; Canadian Institutes of Health Research; National Institutes of Health; Heart and Stroke Foundation of Canada","keywords":"Peroxynitrite; Lipoxin; Chemistry; Intracellular; Lipopolysaccharide; Interleukin 8; Molecular biology; Signal transduction; Biochemistry; Cytokine; Cell biology; Superoxide; Biology; Immunology; Receptor; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001114341,0.0003506202,0.0002639843,0.0001249735,0.00008827463,0.0001855568,0.0001533151,0.0002353197,0.001191785],"category_scores_gemma":[0.0001301684,0.0001049938,0.0002852434,0.00008357163,0.0002625683,0.0001591638,0.000167968,0.0003965656,0.0002881108],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001764838,"about_ca_system_score_gemma":0.0001954537,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002951,"about_ca_topic_score_gemma":0.0004614684,"domain_scores_codex":[0.9999049,0.00002588014,0.00001396944,0.0000122718,0.00001733145,0.00002569266],"domain_scores_gemma":[0.9999337,0.000009587554,0.00002773082,0.000007155194,0.000005680064,0.00001607399],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000959794,0.0001052929,0.000170197,0.00006485215,0.00001517479,0.00005791501,0.00001336596,0.000122816,0.9965134,0.00007373196,0.00003134322,0.001872029],"study_design_scores_gemma":[0.00008674389,0.002818085,0.002861334,0.000006222107,0.00002537599,0.0002218596,0.00002528907,0.0005200924,0.9921119,0.00004226153,0.001275734,0.000005024247],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9958366,0.00214662,0.001204048,0.00004123529,0.00002464478,0.00003371042,0.00009951775,0.00002532581,0.0005881768],"genre_scores_gemma":[0.9956164,0.001094902,0.001374701,0.00007193093,0.00001606374,0.00005069151,0.000374826,0.000007343773,0.00139312],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001191785,"threshold_uncertainty_score":0.003986955,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02266276990558204,"score_gpt":0.251457267703695,"score_spread":0.228794497798113,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}