{"id":"W2073059894","doi":"10.1073/pnas.202296999","title":"Lipoxin A 4 and aspirin-triggered 15-epi-lipoxin A 4 inhibit peroxynitrite formation, NF-κB and AP-1 activation, and IL-8 gene expression in human leukocytes","year":2002,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Peroxisome Proliferator-Activated Receptors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":250,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Hôpital Maisonneuve-Rosemont","funders":"National Institute of Dental and Craniofacial Research; Canadian Institutes of Health Research; National Institutes of Health; Heart and Stroke Foundation of Canada","keywords":"Peroxynitrite; Lipoxin; Chemistry; Intracellular; Lipopolysaccharide; Interleukin 8; Molecular biology; Signal transduction; Biochemistry; Cytokine; Cell biology; Superoxide; Biology; Immunology; Receptor; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007838852,0.0002145773,0.000233812,0.0003137294,0.0003415922,0.00007430155,0.0002983224,0.0002569559,0.000002493082],"category_scores_gemma":[0.0004743148,0.0001703738,0.00004618206,0.0005412111,0.0007199562,0.0002150754,0.000286362,0.0002296297,5.058225e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003720893,"about_ca_system_score_gemma":0.00002665153,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00000318281,"about_ca_topic_score_gemma":7.356317e-7,"domain_scores_codex":[0.9981637,0.00002699867,0.0004781755,0.0004763099,0.0006050515,0.0002497761],"domain_scores_gemma":[0.9991125,0.0000501532,0.0004554646,0.00002383939,0.0002704683,0.00008757861],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000340961,0.000059575,0.004297521,0.00009666618,0.00001343492,1.465135e-8,0.0002951382,0.0000129149,0.9929494,0.0001356347,0.0002595955,0.001846039],"study_design_scores_gemma":[0.0006840861,0.0001196957,0.009245513,0.0001832688,0.000008842644,0.00002240585,0.0001873064,0.0003696845,0.9874036,0.001479885,0.0001044118,0.0001913314],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9978129,0.0009049518,0.000006474134,0.0007803065,0.00001059568,0.0003254,0.00001944106,0.00001115505,0.0001287651],"genre_scores_gemma":[0.9982889,0.0009484197,0.0004176173,0.0001933359,0.00009044322,0.00003597989,0.000003350023,0.00001216011,0.000009846135],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005545801,"threshold_uncertainty_score":0.6947644,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02266276990558204,"score_gpt":0.251457267703695,"score_spread":0.228794497798113,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}