{"id":"W2073080535","doi":"10.1371/journal.pone.0071944","title":"Loss of the Anorexic Response to Systemic 5-Aminoimidazole-4-Carboxamide-1-β-D-Ribofuranoside Administration Despite Reducing Hypothalamic AMP-Activated Protein Kinase Phosphorylation in Insulin-Deficient Rats","year":2013,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Metabolism, Diabetes, and Cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"York University","funders":"Canadian Institutes of Health Research; Ontario Ministry of Research and Innovation; Natural Sciences and Engineering Research Council of Canada; Coordenação de Aperfeiçoamento de Pessoal de Nível Superior","keywords":"Internal medicine; Endocrinology; AMPK; SOCS3; Leptin; AMP-activated protein kinase; Energy homeostasis; Insulin; Protein kinase A; Adiponectin; Diabetes mellitus; Acetyl-CoA carboxylase; Medicine; Chemistry; Phosphorylation; Insulin resistance; Pyruvate carboxylase; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000165167,0.0008121178,0.0005514317,0.0004335401,0.0001510611,0.0002878192,0.0002577313,0.0003478536,0.001184978],"category_scores_gemma":[0.0001330266,0.000258594,0.0003625581,0.0001945497,0.0004938392,0.0003296259,0.0001658026,0.001311909,0.0002421691],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000304207,"about_ca_system_score_gemma":0.0003417471,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007628654,"about_ca_topic_score_gemma":0.001451203,"domain_scores_codex":[0.9998323,0.00001820673,0.00001749943,0.00005191089,0.0000323232,0.00004773734],"domain_scores_gemma":[0.999702,0.00001685062,0.0001136564,0.00003332398,0.00001982373,0.0001142671],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001485274,0.0001477019,0.0002691697,0.00003537685,0.00001265084,0.00004674779,0.00001095535,0.00004983652,0.996428,0.00003540274,0.00002626769,0.001452654],"study_design_scores_gemma":[0.0003040812,0.007254906,0.01510141,0.00001961125,0.00007236774,0.0003127471,0.00007900649,0.001009803,0.9744787,0.00006676238,0.001280081,0.00002051328],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9974483,0.0008565671,0.0008191575,0.00008271974,0.00003185519,0.00002292151,0.0002839883,0.00009746275,0.0003569836],"genre_scores_gemma":[0.9943922,0.001067429,0.001926203,0.0001116722,0.00002719772,0.00009710828,0.0006172592,0.00004288107,0.001718109],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001184978,"threshold_uncertainty_score":0.003964126,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02024208955572211,"score_gpt":0.2223992015398057,"score_spread":0.2021571119840836,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}