{"id":"W2073114644","doi":"10.1371/journal.pgen.1005103","title":"Contribution of Large Region Joint Associations to Complex Traits Genetics","year":2015,"lang":"en","type":"article","venue":"PLoS Genetics","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"Thrombosis and Atherosclerosis Research Institute; University of Toronto; Population Health Research Institute; McMaster University; Hamilton Health Sciences","funders":"","keywords":"Biology; Genetic architecture; Heritability; Genetics; Genome-wide association study; Single-nucleotide polymorphism; Genetic association; Multivariate statistics; Trait; Explained variation; Quantitative trait locus; Evolutionary biology; Gene; Genotype; Statistics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.004686716,0.0007448785,0.0009610906,0.001176161,0.0005620433,0.001589251,0.0007709211,0.0006714807,0.00327078],"category_scores_gemma":[0.01619597,0.000455207,0.001598546,0.001538863,0.001560355,0.0007052728,0.001540586,0.001183476,0.0002615175],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003665364,"about_ca_system_score_gemma":0.0006474785,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003292707,"about_ca_topic_score_gemma":0.002595997,"domain_scores_codex":[0.9952631,0.002708339,0.0001933091,0.001256513,0.0003717685,0.0002070284],"domain_scores_gemma":[0.9802515,0.0151448,0.0016659,0.002096656,0.0003992109,0.0004419418],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001191711,0.0001112224,0.8985277,0.0002432911,0.004092999,0.002109829,0.0007343009,0.0279476,0.01456333,0.008939523,0.0006161856,0.04092229],"study_design_scores_gemma":[0.0001303788,0.0004586892,0.8300133,0.00009040908,0.0019761,0.00302528,0.0003415812,0.1199304,0.002287153,0.03954211,0.002055292,0.0001493068],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9111149,0.003253757,0.08245878,0.0005087287,0.00005608661,0.0000442998,0.0005088788,0.00027712,0.001777444],"genre_scores_gemma":[0.995248,0.0002745411,0.004012217,0.00005027803,0.0000329316,0.00001845911,0.0001273386,0.00003010582,0.0002060654],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004686716,"threshold_uncertainty_score":0.024786,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07904701403300436,"score_gpt":0.3059890177595733,"score_spread":0.2269420037265689,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}