{"id":"W2073120753","doi":"10.1017/s0021932001003613","title":"NATURAL SELECTION AT THE MJD LOCUS: PHENOTYPIC DIVERSITY, SURVIVAL AND FERTILITY AMONG MACHADO-JOSEPH DISEASE PATIENTS FROM THE AZORES","year":2001,"lang":"en","type":"article","venue":"Journal of Biosocial Science","topic":"Genetic Neurodegenerative Diseases","field":"Neuroscience","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université du Québec à Montréal","funders":"European Science Foundation","keywords":"Age of onset; Machado–Joseph disease; Demography; Fertility; Locus (genetics); Disease; Biology; Genetics; Medicine; Internal medicine; Population; Spinocerebellar ataxia; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002259392,0.0001349603,0.0002609698,0.0006578116,0.0005776723,0.0003849983,0.0001610154,0.0001973607,0.000845944],"category_scores_gemma":[0.001199796,0.0001310717,0.0001686939,0.0004004857,0.0003545964,0.0001482908,0.0003365411,0.0001690456,0.00007612563],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002280261,"about_ca_system_score_gemma":0.0001214932,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.006992374,"about_ca_topic_score_gemma":0.009162659,"domain_scores_codex":[0.9998162,0.00004160411,0.00001588018,0.00004844117,0.00003433277,0.00004359807],"domain_scores_gemma":[0.9996862,0.00006120558,0.000123834,0.0000212205,0.00002725156,0.00008025146],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.000134608,0.00004339755,0.9960381,0.000005816642,0.00002502114,0.0003854412,0.0005984928,0.00002046164,0.0009394974,0.00002073906,0.00003930675,0.001749214],"study_design_scores_gemma":[0.00000406115,0.00005644351,0.9988593,0.000001968261,0.000006043806,0.0006617486,0.0002690038,0.00003032339,0.00003618104,0.00001222426,0.00006066261,0.000002094013],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.999842,0.00004074052,0.000007966649,0.00000593583,4.892905e-7,0.000001299272,0.00002740933,2.750404e-7,0.00007372646],"genre_scores_gemma":[0.999827,0.00003389001,0.00001499317,0.000006742877,0.000002072286,0.000001192715,0.00005492834,4.159106e-7,0.00005886531],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006992374,"threshold_uncertainty_score":0.01390332,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02009985126535748,"score_gpt":0.2505430626646582,"score_spread":0.2304432113993007,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}