{"id":"W2073155151","doi":"10.4161/epi.4.6.9392","title":"Targeting of EZH2 to a defined genomic site is sufficient for recruitment of Dnmt3a but not de novo DNA methylation","year":2009,"lang":"en","type":"article","venue":"Epigenetics","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":83,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Florida Institute of Technology","keywords":"Biology; EZH2; DNA methylation; Epigenomics; RNA-Directed DNA Methylation; Histone methylation; Histone methyltransferase; Epigenetics of physical exercise; Epigenetics; Methylation; PRC2; Genetics; Molecular biology; DNA; Gene; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005266407,0.0001724469,0.000243191,0.00009385141,0.00005675134,0.00001089139,0.0001606381,0.0001635551,0.00000871537],"category_scores_gemma":[0.0003163877,0.0001847911,0.0001401204,0.0001302874,0.00003002535,0.000001918873,0.00005816948,0.00004463617,0.000002864067],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003784493,"about_ca_system_score_gemma":0.0001289947,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000136907,"about_ca_topic_score_gemma":0.000009097243,"domain_scores_codex":[0.9985824,0.0000593675,0.0005477699,0.0003379364,0.0001744831,0.0002980928],"domain_scores_gemma":[0.9989437,0.00004474708,0.0002608156,0.0003518733,0.0002693745,0.0001295117],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001336545,0.0001086329,0.001291596,0.00002985466,0.00002794817,2.463126e-7,0.0004642498,0.008317768,0.9824045,0.0001112635,0.00009208739,0.007018179],"study_design_scores_gemma":[0.0004835649,0.001280919,0.01061105,0.00001469164,0.00004495602,4.285427e-7,0.0000499081,0.0009811828,0.9774806,0.0002781221,0.00858631,0.0001882547],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8998677,0.001478552,0.09730535,0.0002847006,0.00009524849,0.0007237614,0.0001333563,0.000005998223,0.0001053556],"genre_scores_gemma":[0.95009,0.0004155042,0.04868669,0.0003332801,0.0001276223,0.00003233023,0.0001433507,0.00002415384,0.0001470585],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05022233,"threshold_uncertainty_score":0.7535562,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03702920663837191,"score_gpt":0.3082358552713236,"score_spread":0.2712066486329517,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}