{"id":"W2073162917","doi":"10.1038/leu.2013.15","title":"Initially disadvantaged, TEL-AML1 cells expand and initiate leukemia in response to irradiation and cooperating mutations","year":2013,"lang":"en","type":"letter","venue":"Leukemia","topic":"Acute Lymphoblastic Leukemia research","field":"Medicine","cited_by":25,"is_retracted":false,"has_abstract":true,"ca_institutions":"Sunnybrook Health Science Centre","funders":"National Cancer Institute; National Heart, Lung, and Blood Institute; Electric Power Research Institute","keywords":"Biology; Molecular biology; Transgene; Haematopoiesis; Genetically modified mouse; Leukemia; Green fluorescent protein; Embryonic stem cell; Gene; Stem cell; Cancer research; Cell biology; Immunology; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity"],"consensus_categories":[],"category_scores_codex":[0.0008311429,0.0007069233,0.001018796,0.001082661,0.0002364564,0.0003167401,0.0002538191,0.001197933,0.0001743467],"category_scores_gemma":[0.001597913,0.0006745125,0.00008367931,0.0006517679,0.0003470368,0.0004055127,0.0003292038,0.002757697,0.0002789902],"about_ca_system_candidate":true,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00742096,"about_ca_system_score_gemma":0.004595826,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001526796,"about_ca_topic_score_gemma":0.00008276861,"domain_scores_codex":[0.9953768,0.0005980475,0.0009649611,0.001155227,0.0008691935,0.00103582],"domain_scores_gemma":[0.9961009,0.002314448,0.0002324836,0.0005875322,0.0002831794,0.0004814465],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.003525716,0.00006833951,0.001869136,0.00228671,0.0003722062,0.01701108,0.01116983,0.0008844881,0.1176701,0.0000446484,0.833033,0.01206476],"study_design_scores_gemma":[0.08804782,0.008081808,0.1549129,0.01351094,0.002160305,0.01136954,0.005402658,0.06909618,0.01239772,0.00192351,0.6222255,0.01087111],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9297531,0.0003196402,0.0004431285,0.06327599,0.0003019576,0.00298297,0.0002395038,0.0001623854,0.002521315],"genre_scores_gemma":[0.5807537,0.0004454001,0.005831602,0.3986376,0.00289106,0.0008805097,0.001037995,0.0004253499,0.009096725],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3489994,"threshold_uncertainty_score":0.9995706,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01770827251705164,"score_gpt":0.2904537892943207,"score_spread":0.272745516777269,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}