{"id":"W2073164785","doi":"10.1016/j.neuron.2010.09.034","title":"Sortilin-Mediated Endocytosis Determines Levels of the Frontotemporal Dementia Protein, Progranulin","year":2010,"lang":"en","type":"article","venue":"Neuron","topic":"Amyotrophic Lateral Sclerosis Research","field":"Medicine","cited_by":579,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia","funders":"National Institute of Neurological Disorders and Stroke; National Institute on Drug Abuse; National Institute on Aging; Canadian Institutes of Health Research","keywords":"Frontotemporal lobar degeneration; Haploinsufficiency; Frontotemporal dementia; Biology; Cell biology; Ubiquitin; Endocytosis; Mutation; Neuroscience; Genetics; Dementia; Cell; Medicine; Internal medicine; Phenotype; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001699099,0.0001510813,0.0002491863,0.00005329093,0.00007208357,0.00001789161,0.0002688211,0.0001067377,0.0005247887],"category_scores_gemma":[0.0003515117,0.00009142543,0.0001367356,0.000202577,0.0002060748,0.00007609826,0.0001402684,0.0004913692,0.00003769699],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001491616,"about_ca_system_score_gemma":0.0001204832,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001304242,"about_ca_topic_score_gemma":0.0001277489,"domain_scores_codex":[0.9983908,0.00008706925,0.0003480205,0.0002709426,0.0005653191,0.0003378402],"domain_scores_gemma":[0.9990095,0.00004028235,0.0001316008,0.0005401772,0.0001433663,0.0001350373],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0001147568,0.0001275629,0.1161824,0.00006010366,0.00002673767,0.00001124393,0.00005040378,2.822844e-7,0.8742079,0.000007592232,0.0001447503,0.009066265],"study_design_scores_gemma":[0.001125275,0.0002903065,0.8429896,0.00004971794,0.00004777842,0.00001256231,0.000004067111,0.0002328965,0.1528068,0.00003163865,0.002329498,0.00007991875],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9961689,0.00004096383,0.000006934903,0.001844232,0.0002028213,0.001293019,0.000018273,0.00005415651,0.0003707352],"genre_scores_gemma":[0.9984378,0.000004547766,0.0005529267,0.0001692243,0.0001411418,0.00008820296,0.000005546208,0.00003093186,0.0005697421],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7268072,"threshold_uncertainty_score":0.5746069,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03019832833392997,"score_gpt":0.2868415814431858,"score_spread":0.2566432531092558,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}