{"id":"W2073194177","doi":"10.2165/00063030-200620010-00001","title":"The Future of Antisense Oligonucleotides in the Treatment of Respiratory Diseases","year":2006,"lang":"en","type":"review","venue":"BioDrugs","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":17,"is_retracted":false,"has_abstract":false,"ca_institutions":"NOSM University; University of Alberta","funders":"National Heart, Lung, and Blood Institute","keywords":"Oligonucleotide; Genetic enhancement; Small interfering RNA; RNA interference; RNA; Immune system; Biology; Translation (biology); Medicine; Pharmacology; Messenger RNA; Computational biology; Gene; Immunology; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001152664,0.001145843,0.00179481,0.00138923,0.0003632618,0.001108657,0.001461145,0.00208781,0.003407906],"category_scores_gemma":[0.0005581963,0.0003539616,0.0004757763,0.001380956,0.0009184713,0.002157359,0.0005981786,0.002739101,0.002361085],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000842428,"about_ca_system_score_gemma":0.0009154084,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009622602,"about_ca_topic_score_gemma":0.002305159,"domain_scores_codex":[0.9997852,0.00004406715,0.00002216262,0.00003312763,0.00009054651,0.00002486145],"domain_scores_gemma":[0.9997191,0.0001426056,0.00003542606,0.000007620964,0.00006421748,0.00003100785],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002306247,0.0001552715,0.0001180003,0.006503966,0.0000702371,0.0004302654,0.00007413318,0.0009782361,0.01276863,0.009931551,0.02788503,0.940854],"study_design_scores_gemma":[0.00008277588,0.000248777,0.0003435391,0.0009047556,0.00007975882,0.001449916,0.00005507671,0.00038674,0.002196403,0.004351832,0.9898733,0.00002707962],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001952569,0.9967398,0.0009684993,0.0005706737,0.0004551654,0.000006546844,0.00001052387,0.00001897927,0.001034532],"genre_scores_gemma":[0.001212281,0.9957628,0.001051881,0.0003953377,0.0003546973,0.00001505601,0.00002348381,0.00000302137,0.001181323],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003407906,"threshold_uncertainty_score":0.01140052,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02334919196402986,"score_gpt":0.3058975377542738,"score_spread":0.282548345790244,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}