{"id":"W2073194177","doi":"10.2165/00063030-200620010-00001","title":"The Future of Antisense Oligonucleotides in the Treatment of Respiratory Diseases","year":2006,"lang":"en","type":"review","venue":"BioDrugs","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":17,"is_retracted":false,"has_abstract":false,"ca_institutions":"NOSM University; University of Alberta","funders":"National Heart, Lung, and Blood Institute","keywords":"Oligonucleotide; Genetic enhancement; Small interfering RNA; RNA interference; RNA; Immune system; Biology; Translation (biology); Medicine; Pharmacology; Messenger RNA; Computational biology; Gene; Immunology; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009717399,0.000215293,0.0004682045,0.00004447118,0.00004123974,0.00001238328,0.0003365985,0.0001606799,0.000002204881],"category_scores_gemma":[0.000009114109,0.0001017139,0.0004315319,0.0001075762,0.0001461357,0.000001146729,0.00002947231,0.00004608118,0.000004016055],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001284419,"about_ca_system_score_gemma":0.0001351112,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003755507,"about_ca_topic_score_gemma":0.00008726559,"domain_scores_codex":[0.9989493,0.0001862002,0.0004013486,0.0002138901,0.0001034224,0.0001457644],"domain_scores_gemma":[0.9990687,0.00004971989,0.0002542785,0.0005659799,0.0000424782,0.00001885363],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00002968515,0.000240501,0.0001526013,0.0008306172,0.0001279506,0.000008181252,0.00004299644,4.882997e-7,0.000345581,0.00004286038,0.007268562,0.99091],"study_design_scores_gemma":[0.0001156461,0.0003790816,0.0001947554,0.000360533,0.000162783,0.000003125256,0.00008685871,8.489607e-8,0.001060337,0.000006424188,0.9975253,0.000105016],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.01742215,0.9816609,3.304024e-7,0.00001672161,0.0001514608,0.0003209204,0.0002295571,0.000001889108,0.0001960847],"genre_scores_gemma":[0.002518828,0.9967026,0.000005160671,0.00002563318,0.000401596,0.00003980805,0.0001316128,0.0000138005,0.0001609547],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.990805,"threshold_uncertainty_score":0.4147773,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02334919196402986,"score_gpt":0.3058975377542738,"score_spread":0.282548345790244,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}