{"id":"W2073206520","doi":"10.1016/s1046-2023(03)00083-5","title":"Measurement of histone acetyltransferase and histone deacetylase activities and kinetics of histone acetylation","year":2003,"lang":"en","type":"article","venue":"Methods","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":44,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Manitoba; Children's Hospital Research Institute of Manitoba","funders":"","keywords":"Histone Acetyltransferases; Acetylation; Histone H2A; Histone deacetylase 2; Histone methyltransferase; Histone deacetylase; Histone code; SAP30; HDAC4; Histone H1; Biochemistry; HDAC11; Histone acetyltransferase; Chemistry; Histone; DNA; Nucleosome; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001044503,0.00135362,0.0005956184,0.001010774,0.0007087164,0.001227645,0.001064436,0.0005964189,0.003281975],"category_scores_gemma":[0.0008810985,0.0008266621,0.0005498033,0.001442789,0.0006346705,0.001035222,0.0005570844,0.003156667,0.00218679],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009411187,"about_ca_system_score_gemma":0.0008410396,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001680763,"about_ca_topic_score_gemma":0.003405188,"domain_scores_codex":[0.9991678,0.0001035486,0.00008072722,0.0002311464,0.0002724201,0.0001443509],"domain_scores_gemma":[0.9989929,0.0003535431,0.0001116785,0.000219358,0.0001622141,0.0001602855],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002194204,0.00006977122,0.0002308381,0.00006651853,0.00001326572,0.00001010435,0.00002323221,0.00006196514,0.9953632,0.0005788472,0.0001231942,0.003239657],"study_design_scores_gemma":[0.00001622206,0.0000609375,0.001144806,0.000004224849,0.00001534483,0.00003835854,0.00001167346,0.0005464901,0.9951937,0.0001908516,0.002769707,0.000007736399],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"methods","genre_gemma":"methods","genre_scores_codex":[0.2934358,0.009992467,0.6636903,0.000871352,0.001013227,0.0007454348,0.006499649,0.002824562,0.02092719],"genre_scores_gemma":[0.5675884,0.01192932,0.3271939,0.0005585311,0.0003830142,0.00261879,0.01413031,0.001676694,0.07392111],"genre_candidate":"methods","genre_consensus":"methods","teacher_disagreement_score":0.003281975,"threshold_uncertainty_score":0.01097929,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03431780979323379,"score_gpt":0.3990216270395416,"score_spread":0.3647038172463078,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}