{"id":"W2073213467","doi":"10.1021/bi702518m","title":"Rifampicin Does Not Prevent Amyloid Fibril Formation by Human Islet Amyloid Polypeptide but Does Inhibit Fibril Thioflavin-T Interactions: Implications for Mechanistic Studies of β-Cell Death","year":2008,"lang":"en","type":"article","venue":"Biochemistry","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":93,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"National Institute of General Medical Sciences","keywords":"Amyloid (mycology); Islet; Chemistry; Rifampicin; Thioflavin; Amyloid disease; Fibril; Biochemistry; Biophysics; Amyloid fibril; Pharmacology; Diabetes mellitus; Alzheimer's disease; Biology; Internal medicine; Endocrinology; Disease; Amyloid β; Medicine; Antibiotics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001898425,0.000293621,0.0002179811,0.00009656042,0.0001067662,0.0001973031,0.0001637755,0.0003387912,0.0005472453],"category_scores_gemma":[0.0002267723,0.00009738016,0.0001536043,0.0000847639,0.0002653059,0.0001664162,0.0001035554,0.0003389468,0.0002017619],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001912046,"about_ca_system_score_gemma":0.0001670712,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008463181,"about_ca_topic_score_gemma":0.000762759,"domain_scores_codex":[0.9998381,0.00004846571,0.00001579688,0.00002776545,0.00004072489,0.00002900723],"domain_scores_gemma":[0.9997781,0.00008345797,0.00005350762,0.00003338196,0.00002108864,0.00003045872],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001860109,0.00003141671,0.0001555353,0.00004239753,0.000006450271,0.00008735782,0.00001607885,0.00004098265,0.9984497,0.00004432744,0.00002882852,0.0009109563],"study_design_scores_gemma":[0.00002596458,0.0004553192,0.001686168,0.000003638037,0.000009236121,0.0002824963,0.00001235356,0.0002368429,0.9965153,0.00002417842,0.0007452884,0.000003083871],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9895431,0.005384558,0.002495148,0.0001550675,0.00003481449,0.00004298901,0.0001589928,0.00008249274,0.002102791],"genre_scores_gemma":[0.9968289,0.0008944513,0.001080689,0.00006718853,0.0000100905,0.00001080379,0.0001584579,0.00001717293,0.0009321872],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008463181,"threshold_uncertainty_score":0.001830757,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04697377109972817,"score_gpt":0.346809592987547,"score_spread":0.2998358218878189,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}