{"id":"W2073213467","doi":"10.1021/bi702518m","title":"Rifampicin Does Not Prevent Amyloid Fibril Formation by Human Islet Amyloid Polypeptide but Does Inhibit Fibril Thioflavin-T Interactions: Implications for Mechanistic Studies of β-Cell Death","year":2008,"lang":"en","type":"article","venue":"Biochemistry","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":93,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"National Institute of General Medical Sciences","keywords":"Amyloid (mycology); Islet; Chemistry; Rifampicin; Thioflavin; Amyloid disease; Fibril; Biochemistry; Biophysics; Amyloid fibril; Pharmacology; Diabetes mellitus; Alzheimer's disease; Biology; Internal medicine; Endocrinology; Disease; Amyloid β; Medicine; Antibiotics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009686639,0.0002658941,0.0003913278,0.00007650115,0.0003515304,0.00001702921,0.0001231786,0.00008452864,0.00004765244],"category_scores_gemma":[0.0001698784,0.0001852965,0.000218465,0.0001018855,0.000143412,0.0001435246,0.00008446772,0.0001280676,0.00001375211],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002384059,"about_ca_system_score_gemma":0.0001754821,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001037546,"about_ca_topic_score_gemma":0.000008765676,"domain_scores_codex":[0.99845,0.00002850999,0.0005017577,0.0003827488,0.0002877642,0.0003491525],"domain_scores_gemma":[0.9985175,0.0001697846,0.0002625974,0.0004787256,0.0003416525,0.0002296998],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002157776,0.0007168492,0.001642918,0.0007836782,0.001155508,0.000005791715,0.000149455,3.489365e-7,0.9907938,0.00004390697,0.004367608,0.0001243538],"study_design_scores_gemma":[0.001369763,0.0002552982,0.0007782521,0.0002457628,0.0004359435,0.00004649934,0.0006251344,0.00001941853,0.995331,0.0005296917,0.0001770851,0.0001861643],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9936309,0.002382733,0.0001942073,0.0006396935,0.00004699705,0.0008916628,0.001685261,0.00007174111,0.0004567463],"genre_scores_gemma":[0.9937907,0.0007305504,0.000885715,0.00008445288,0.0001750477,0.0003515969,0.001069787,0.0000320072,0.00288018],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004537183,"threshold_uncertainty_score":0.7556173,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04697377109972817,"score_gpt":0.346809592987547,"score_spread":0.2998358218878189,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}