{"id":"W2073234751","doi":"10.1038/nature05495","title":"Aberrant innate immune response in lethal infection of macaques with the 1918 influenza virus","year":2007,"lang":"en","type":"article","venue":"Nature","topic":"Influenza Virus Research Studies","field":"Medicine","cited_by":942,"is_retracted":false,"has_abstract":false,"ca_institutions":"Canadian Science Centre for Human and Animal Health; Canadian Food Inspection Agency; University of Manitoba; Public Health Agency of Canada","funders":"Core Research for Evolutional Science and Technology; Japan Science and Technology Agency; Japan Society for the Promotion of Science; Public Health Agency; Public Health Agency of Canada","keywords":"Virulence; Virus; Biology; Virology; Immune system; Innate immune system; Influenza A virus subtype H5N1; Influenza A virus; Immunology; Macaque; Pandemic; Phenotype; Medicine; Gene; Disease; Coronavirus disease 2019 (COVID-19); Genetics; Infectious disease (medical specialty)","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002398954,0.000304647,0.0002873933,0.0004017391,0.0004260525,0.0003327546,0.0001387104,0.000538121,0.0008594786],"category_scores_gemma":[0.0003818244,0.0001795571,0.0001869918,0.00007402511,0.0005073149,0.0002079703,0.0002621851,0.0007548191,0.0002154449],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002925408,"about_ca_system_score_gemma":0.0001579983,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001049384,"about_ca_topic_score_gemma":0.001275338,"domain_scores_codex":[0.9998302,0.00003084342,0.00001076347,0.00003320592,0.00002137217,0.00007360973],"domain_scores_gemma":[0.9998287,0.00002890583,0.00004034675,0.00002569477,0.00002277503,0.00005350808],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001240708,0.00007223004,0.01102333,0.00004116082,0.00001595957,0.001010229,0.0002969288,0.00004760625,0.9842004,0.0001627768,0.0001122404,0.001776453],"study_design_scores_gemma":[0.0001168768,0.003928332,0.5275289,0.0000446914,0.0001230417,0.0194143,0.002187659,0.002327538,0.4397762,0.0009174799,0.003590401,0.00004467704],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9993439,0.0001997877,0.0001341541,0.00002823417,0.000009035824,0.000005443676,0.00004716205,0.00000754939,0.0002247047],"genre_scores_gemma":[0.999225,0.00009731444,0.0001350178,0.00003945633,0.000006096525,0.00001272989,0.00008588985,0.000003395542,0.0003950128],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001049384,"threshold_uncertainty_score":0.002875209,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03039570529980008,"score_gpt":0.3769373946720303,"score_spread":0.3465416893722302,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}