{"id":"W2073236435","doi":"10.1002/ajmg.10221","title":"Possible association of NTDs with a polyhistidine tract polymorphism in the <i>ZIC2</i> gene","year":2002,"lang":"en","type":"article","venue":"American Journal of Medical Genetics","topic":"Hedgehog Signaling Pathway Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":35,"is_retracted":false,"has_abstract":true,"ca_institutions":"Columbia College","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development; National Institute of Diabetes and Digestive and Kidney Diseases","keywords":"Genetics; Neural tube; Biology; Holoprosencephaly; Mutation; Gene; Fetus; Embryo; Pregnancy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001133698,0.0001240654,0.0003028816,0.00007148323,0.00003325058,0.000009473598,0.0004149738,0.00009792732,0.00002857543],"category_scores_gemma":[0.0005653842,0.00007952087,0.00009198525,0.0002841718,0.0002572778,0.000002380429,0.00003832528,0.0002775067,0.000001412274],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003045994,"about_ca_system_score_gemma":0.0001331663,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002567525,"about_ca_topic_score_gemma":0.00002197443,"domain_scores_codex":[0.9979914,0.0002341611,0.0004737944,0.0001245623,0.0009487898,0.0002272715],"domain_scores_gemma":[0.9988333,0.0001378833,0.0005760284,0.0001819984,0.0001553442,0.000115462],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004881753,0.00238542,0.3293675,0.00005753798,0.0009798933,0.0005617952,0.006107388,0.0006519882,0.4811979,0.00002735158,0.01686656,0.1613085],"study_design_scores_gemma":[0.01892898,0.05289336,0.2320948,0.001002545,0.001220018,0.006059521,0.01220165,0.002428477,0.5448683,0.0001798087,0.1257702,0.002352317],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9904329,0.004496282,0.001137264,0.003575026,0.00007752542,0.00005883002,0.000008638372,0.00000150325,0.000212077],"genre_scores_gemma":[0.9944617,0.002721169,0.001525164,0.000863629,0.0003370989,0.000002118278,0.000002727299,0.00001456417,0.0000718292],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1589561,"threshold_uncertainty_score":0.3242767,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01108168217895641,"score_gpt":0.2446599145917702,"score_spread":0.2335782324128138,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}