{"id":"W2073245585","doi":"10.1021/ja505592h","title":"Hydroxyproline-Derived Pseudoenantiomeric [2.2.1] Bicyclic Phosphines: Asymmetric Synthesis of (+)- and (−)-Pyrrolines","year":2014,"lang":"en","type":"article","venue":"Journal of the American Chemical Society","topic":"Synthesis and Biological Activity","field":"Biochemistry, Genetics and Molecular Biology","cited_by":191,"is_retracted":false,"has_abstract":true,"ca_institutions":"Brock University","funders":"National Institute of General Medical Sciences; U.S. Public Health Service; National Institutes of Health","keywords":"Chemistry; Diastereomer; Combinatorial chemistry; Bicyclic molecule; Catalysis; Organic chemistry; Stereochemistry; Medicinal chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004359157,0.0001650733,0.0005008593,0.00002333121,0.00005425515,0.00001110988,0.0003731807,0.00009176927,0.00000250986],"category_scores_gemma":[0.001365523,0.00008892514,0.0005464214,0.0003720863,0.000630854,0.000005494533,0.0001826304,0.0001592485,4.474412e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001402846,"about_ca_system_score_gemma":0.00003003427,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002178381,"about_ca_topic_score_gemma":4.992997e-7,"domain_scores_codex":[0.9988903,0.0001084976,0.0004079247,0.000195384,0.0002028389,0.0001950742],"domain_scores_gemma":[0.9984435,0.0001991507,0.0009085548,0.0002344768,0.0001216094,0.00009273872],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008878459,0.0001176038,0.01788112,0.00001762872,0.0001157642,1.651339e-7,0.000009740058,0.000005061437,0.9573172,0.000002723534,0.0004827272,0.02396149],"study_design_scores_gemma":[0.0002344658,0.0002147104,0.03552769,0.00002888788,0.00007629359,0.00004527396,0.00005183043,0.0001966603,0.9620023,0.00009397081,0.001397288,0.0001306696],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9983022,0.0003324954,0.00029528,0.0008851805,0.00004870975,0.00005189816,0.00000538397,0.000003958477,0.00007496097],"genre_scores_gemma":[0.9963787,0.0007772048,0.001904889,0.0005550349,0.0003568518,0.000002762053,6.077497e-7,0.00001322224,0.00001077267],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02383082,"threshold_uncertainty_score":0.3626262,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007397334326852341,"score_gpt":0.2353633582520243,"score_spread":0.227966023925172,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}