{"id":"W2073248040","doi":"10.1016/j.bmcl.2010.11.118","title":"The identification of substituted benzothiophene derivatives as PGE2 subtype 4 receptor antagonists: From acid to non-acid","year":2010,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Inflammatory mediators and NSAID effects","field":"Medicine","cited_by":15,"is_retracted":false,"has_abstract":false,"ca_institutions":"TransCanada (Canada); Merck Canada Inc. (Canada)","funders":"","keywords":"Benzothiophene; Chemistry; Antagonist; Stereochemistry; Pharmacology; Chemical synthesis; Receptor; Biochemistry; In vitro; Organic chemistry; Thiophene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001757481,0.0003190071,0.0002664725,0.0002324108,0.0001745174,0.0002791178,0.0003241554,0.0002681058,0.002974956],"category_scores_gemma":[0.0001789189,0.0002217661,0.000201693,0.0002575878,0.0002502944,0.0003264706,0.0002497918,0.0004916398,0.0007129816],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002382687,"about_ca_system_score_gemma":0.0002913628,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006487815,"about_ca_topic_score_gemma":0.001542432,"domain_scores_codex":[0.9999363,0.00001585544,0.000003678831,0.000006668316,0.00001580474,0.00002155854],"domain_scores_gemma":[0.9999462,0.00000862752,0.00001306161,0.000007190862,0.00001201662,0.00001282098],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001108366,0.0001255376,0.0003641521,0.0002713936,0.00002441797,0.0004050642,0.00009943845,0.000677725,0.9623148,0.002574729,0.0007187954,0.03131552],"study_design_scores_gemma":[0.0002326957,0.003937262,0.003045322,0.00004142167,0.00008412887,0.0008287174,0.00006376049,0.001697232,0.9527726,0.0005994465,0.03666123,0.00003616471],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.930618,0.03626749,0.01594883,0.0009708059,0.0002528512,0.0003002041,0.0007620411,0.0002241879,0.01465554],"genre_scores_gemma":[0.9562012,0.02412883,0.006143204,0.0003186264,0.00007996096,0.00008282984,0.0004562857,0.00003354277,0.01255552],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002974956,"threshold_uncertainty_score":0.009952247,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004908775098882982,"score_gpt":0.2349277734307636,"score_spread":0.2300189983318806,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}