{"id":"W2073252878","doi":"10.1194/jlr.m600510-jlr200","title":"Atorvastatin decreases lipoprotein lipase and endothelial lipase expression in human THP-1 macrophages","year":2007,"lang":"en","type":"article","venue":"Journal of Lipid Research","topic":"Lipoproteins and Cardiovascular Health","field":"Medicine","cited_by":34,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Paul's Hospital; University of British Columbia","funders":"Canadian Institutes of Health Research; Heart and Stroke Foundation of British Columbia and Yukon; Heart and Stroke Foundation of Canada","keywords":"Atorvastatin; Lipoprotein lipase; Endocrinology; Internal medicine; Chemistry; Simvastatin; Liver X receptor; Biology; Biochemistry; Medicine; Adipose tissue; Nuclear receptor; Transcription factor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000216236,0.0003028605,0.000427237,0.0002210997,0.0001927989,0.0002823408,0.0001734627,0.0002743322,0.001600341],"category_scores_gemma":[0.0001168138,0.0001328614,0.0004155449,0.0002282432,0.000198204,0.0001546669,0.000175932,0.0004744979,0.0007422662],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001985723,"about_ca_system_score_gemma":0.0002975114,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001080038,"about_ca_topic_score_gemma":0.001821122,"domain_scores_codex":[0.9997469,0.00005229191,0.00004590813,0.00003490286,0.00006031852,0.00005977952],"domain_scores_gemma":[0.9999249,0.0000133467,0.00001403265,0.00001260278,0.00001837098,0.00001674558],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007118221,0.0001045593,0.0003596486,0.0001362564,0.00001987497,0.00008731063,0.00003780264,0.00003949558,0.9963851,0.0000317325,0.0001540432,0.001932339],"study_design_scores_gemma":[0.0001741651,0.002025112,0.01783777,0.00001997952,0.00009927668,0.0004535817,0.0001509195,0.0008313984,0.9725853,0.00007737518,0.005731049,0.0000142499],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9847574,0.00846566,0.002867104,0.000488833,0.0001432301,0.00006516388,0.001119477,0.00009805075,0.001994993],"genre_scores_gemma":[0.9819098,0.006971606,0.002798509,0.000352346,0.00007824062,0.0001306124,0.001726618,0.00002532175,0.006007014],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001600341,"threshold_uncertainty_score":0.005353749,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04994967058178814,"score_gpt":0.398575946450454,"score_spread":0.3486262758686658,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}