{"id":"W2073271453","doi":"10.1001/archneurol.2011.3354","title":"Amyloid-β–Associated Clinical Decline Occurs Only in the Presence of Elevated P-tau","year":2012,"lang":"en","type":"article","venue":"Archives of Neurology","topic":"Dementia and Cognitive Impairment Research","field":"Medicine","cited_by":139,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Center for Advancing Translational Sciences; University of California, Los Angeles; National Institute of Biomedical Imaging and Bioengineering; University of California, San Diego; Genentech; U.S. Food and Drug Administration; National Institutes of Health; Eisai; National Institute of Neurological Disorders and Stroke; Northern California Institute for Research and Education; F. Hoffmann-La Roche; National Center for Research Resources; Elan; Novartis; Medpace; GlaxoSmithKline; AstraZeneca; Eli Lilly and Company; Bristol-Myers Squibb; Alzheimer's Disease Neuroimaging Initiative; Pfizer; Synarc; National Institute on Aging; Alzheimer's Association","keywords":"Clinical Dementia Rating; Alzheimer's disease; Dementia; Cognitive decline; Longitudinal study; Neurodegeneration; Internal medicine; Cerebrospinal fluid; Cohort; Psychology; Disease; Medicine; Pathology","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009977994,0.00009364666,0.0003342591,0.0001567316,0.00002046304,0.000002076823,0.0002551138,0.00006620966,0.00007449181],"category_scores_gemma":[0.001838686,0.00006409641,0.0001252554,0.0002271549,0.0005527012,0.00004376822,0.0001508631,0.0004231568,0.000008475155],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000001868062,"about_ca_system_score_gemma":0.00009526692,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005557795,"about_ca_topic_score_gemma":0.00003527544,"domain_scores_codex":[0.9976812,0.0009623858,0.0005035872,0.000173533,0.0002787613,0.0004005198],"domain_scores_gemma":[0.9967655,0.002687802,0.000163084,0.0002583713,0.00005023428,0.00007500753],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001369216,0.001631457,0.9808185,0.00002622114,0.00006190683,0.00002862304,0.0004480563,8.266801e-7,0.005943397,0.0003321759,0.0002393473,0.009100307],"study_design_scores_gemma":[0.001952255,0.002870543,0.992366,0.00002121795,0.00004836993,0.0000328985,0.00007081569,0.0001212263,0.0009116384,0.0008853914,0.0006764225,0.00004322319],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9918571,0.0001156951,0.00004133632,0.002853984,0.00008019344,0.000386013,0.00001045965,0.000009609104,0.00464558],"genre_scores_gemma":[0.9977831,0.0001958745,0.00007279037,0.001735227,0.00005470027,0.00001146425,0.00002266234,0.000008564845,0.0001156364],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01154753,"threshold_uncertainty_score":0.2613775,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04137759839039715,"score_gpt":0.375141050322278,"score_spread":0.3337634519318808,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}