{"id":"W2073291466","doi":"10.4061/2011/251517","title":"A Novel Mouse Model of Alzheimer's Disease with Chronic Estrogen Deficiency Leads to Glial Cell Activation and Hypertrophy","year":2011,"lang":"en","type":"article","venue":"Journal of Aging Research","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":27,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Université de Montréal; Montreal Clinical Research Institute","funders":"Canadian Institutes of Health Research; Johns Hopkins University; Alzheimer's Association","keywords":"Astrocyte; Microglia; Endocrinology; Hippocampus; Internal medicine; Estrogen; Hippocampal formation; Amyloid precursor protein; Presenilin; Biology; Hyperphosphorylation; Ovariectomized rat; Medicine; Alzheimer's disease; Neuroscience; Central nervous system; Cell biology; Disease; Kinase; Inflammation","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002911582,0.00102512,0.0004803391,0.001285387,0.0003895769,0.0002894507,0.0003722234,0.0006490199,0.002731107],"category_scores_gemma":[0.0001002138,0.0003284155,0.0004041481,0.0004141057,0.0005186074,0.0003740963,0.0003903623,0.0007802459,0.0006774754],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002721453,"about_ca_system_score_gemma":0.0002523621,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004641978,"about_ca_topic_score_gemma":0.001249393,"domain_scores_codex":[0.9998017,0.0000273902,0.00002902554,0.00006602728,0.00004117402,0.00003472929],"domain_scores_gemma":[0.99984,0.000019377,0.00005547445,0.00002113816,0.00002066539,0.00004338414],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000705112,0.0003022545,0.0006501619,0.00009699998,0.00001917601,0.0004726342,0.00008658819,0.00004465977,0.9935987,0.0006780087,0.0001498913,0.003195822],"study_design_scores_gemma":[0.0007351106,0.006682222,0.02605814,0.0001541853,0.0004191035,0.0103476,0.0003593823,0.001645728,0.9059172,0.001589092,0.04603706,0.00005514976],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.982098,0.002790302,0.009144308,0.0003419858,0.0001358113,0.0002392159,0.001566564,0.0002733688,0.003410425],"genre_scores_gemma":[0.9347428,0.007075467,0.01950723,0.0003937614,0.000101133,0.0009144535,0.003248485,0.0001393164,0.03387738],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002731107,"threshold_uncertainty_score":0.009136498,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1017665401342581,"score_gpt":0.3489031694322546,"score_spread":0.2471366292979965,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}