{"id":"W2073291466","doi":"10.4061/2011/251517","title":"A Novel Mouse Model of Alzheimer's Disease with Chronic Estrogen Deficiency Leads to Glial Cell Activation and Hypertrophy","year":2011,"lang":"en","type":"article","venue":"Journal of Aging Research","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":27,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Université de Montréal; Montreal Clinical Research Institute","funders":"Canadian Institutes of Health Research; Johns Hopkins University; Alzheimer's Association","keywords":"Astrocyte; Microglia; Endocrinology; Hippocampus; Internal medicine; Estrogen; Hippocampal formation; Amyloid precursor protein; Presenilin; Biology; Hyperphosphorylation; Ovariectomized rat; Medicine; Alzheimer's disease; Neuroscience; Central nervous system; Cell biology; Disease; Kinase; Inflammation","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004635986,0.0001338421,0.0002716323,0.0005764098,0.0001154271,0.0000251474,0.0001500236,0.00003799665,0.00002168943],"category_scores_gemma":[0.00008317198,0.0000921036,0.00008717446,0.0003337062,0.0001916441,0.000229971,0.00009310834,0.0003797847,0.000006203748],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001555845,"about_ca_system_score_gemma":0.002409632,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001276813,"about_ca_topic_score_gemma":0.000002479756,"domain_scores_codex":[0.9977903,0.00006043238,0.0002827497,0.0002052591,0.001227598,0.0004337052],"domain_scores_gemma":[0.9977734,0.00005156544,0.0001204741,0.0002508074,0.0008848814,0.0009188512],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.02741824,0.01464607,0.3092877,0.001244711,0.005917191,0.0008674812,0.002961776,0.001703775,0.6177652,0.0006742824,0.0007426214,0.016771],"study_design_scores_gemma":[0.0163205,0.01863264,0.1016468,0.001982566,0.002401023,0.0002651496,0.0007611678,0.007746486,0.8490144,0.0006038701,0.00004320759,0.0005822156],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9932217,0.00499745,0.0006584026,0.00026876,0.00001033744,0.0004092704,0.00001621973,0.000007014038,0.0004108534],"genre_scores_gemma":[0.9950954,0.0001823996,0.004511422,0.00002691901,0.00008619303,0.00001300222,0.000002699642,0.00002846764,0.0000535327],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2312492,"threshold_uncertainty_score":0.4274584,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1017665401342581,"score_gpt":0.3489031694322546,"score_spread":0.2471366292979965,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}