{"id":"W2073315036","doi":"10.1038/nsmb1042","title":"Transcription promotes contraction of CAG repeat tracts in human cells","year":2006,"lang":"en","type":"article","venue":"Nature Structural & Molecular Biology","topic":"Genetic Neurodegenerative Diseases","field":"Neuroscience","cited_by":160,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"National Institute of General Medical Sciences; Natural Sciences and Engineering Research Council of Canada; National Institutes of Health","keywords":"MSH2; MSH6; Transcription (linguistics); Nucleotide excision repair; Gene knockdown; Biology; Cell biology; DNA repair; Molecular biology; DNA; DNA replication; DNA mismatch repair; Genetics; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001934825,0.0001827874,0.0002249925,0.0002028502,0.0002176837,0.0004901633,0.0001422895,0.0002925645,0.002879289],"category_scores_gemma":[0.0002963984,0.0001743421,0.0002208558,0.0001625929,0.0002969186,0.0001402079,0.0002446791,0.0005275744,0.0007579543],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003711703,"about_ca_system_score_gemma":0.0003069499,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001903957,"about_ca_topic_score_gemma":0.002215384,"domain_scores_codex":[0.9998631,0.00002805872,0.000008241353,0.00003527917,0.00002679724,0.00003846861],"domain_scores_gemma":[0.9997614,0.0001044156,0.00002124856,0.0000407614,0.00002687922,0.00004529094],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001329167,0.00001440872,0.0003779596,0.00001351262,0.000002978793,0.00007303599,0.00004051496,0.00005759435,0.9977546,0.0002350547,0.0001851957,0.001112332],"study_design_scores_gemma":[0.00004847948,0.0002130263,0.01156231,0.00001035194,0.00001058613,0.0004527051,0.0001121653,0.001448918,0.9778734,0.0002564474,0.008004745,0.000006751824],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9910944,0.001342991,0.002387979,0.0002953628,0.00005521607,0.00001698085,0.000408896,0.0001225954,0.004275609],"genre_scores_gemma":[0.9933212,0.0004676383,0.001118851,0.000118519,0.00003524412,0.00001851768,0.001208188,0.00006703542,0.003644648],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002879289,"threshold_uncertainty_score":0.00963217,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007593295807881744,"score_gpt":0.288073546535696,"score_spread":0.2804802507278142,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}