{"id":"W2073315036","doi":"10.1038/nsmb1042","title":"Transcription promotes contraction of CAG repeat tracts in human cells","year":2006,"lang":"en","type":"article","venue":"Nature Structural & Molecular Biology","topic":"Genetic Neurodegenerative Diseases","field":"Neuroscience","cited_by":160,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"National Institute of General Medical Sciences; Natural Sciences and Engineering Research Council of Canada; National Institutes of Health","keywords":"MSH2; MSH6; Transcription (linguistics); Nucleotide excision repair; Gene knockdown; Biology; Cell biology; DNA repair; Molecular biology; DNA; DNA replication; DNA mismatch repair; Genetics; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00005241702,0.0001902748,0.0002310531,0.0001414342,0.0000582732,0.0000133288,0.0001758769,0.0002901092,0.0000287194],"category_scores_gemma":[0.0001279111,0.0001645512,0.00009910418,0.000218503,0.0001617755,0.00006120409,0.00001631972,0.0003895851,0.000001310519],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002904167,"about_ca_system_score_gemma":0.00002517929,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001038213,"about_ca_topic_score_gemma":0.00006788222,"domain_scores_codex":[0.9984246,0.0003450877,0.0003139403,0.0005045588,0.0001450912,0.0002666563],"domain_scores_gemma":[0.9995036,0.00003769741,0.0001475477,0.0002123277,0.00005944048,0.00003944239],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003702623,0.00003095104,0.0005173123,0.00001296529,0.000002263854,0.00002709859,0.00002107796,0.0002300287,0.9905381,0.008264813,0.00001686968,0.0003014597],"study_design_scores_gemma":[0.0005058364,0.0001460827,0.03005984,0.000007158795,0.00001284638,0.00001952705,0.000004676299,0.00005617721,0.9619509,0.007030278,0.00006590258,0.000140788],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9983017,0.0002633566,0.000148067,0.0001996692,0.0003671942,0.0003843953,0.00005317056,0.0000302112,0.000252165],"genre_scores_gemma":[0.9993556,0.000004272601,0.0001766931,0.0003028411,0.00005502593,0.00001041107,0.00004707857,0.00001604644,0.00003202224],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02954253,"threshold_uncertainty_score":0.6710204,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007593295807881744,"score_gpt":0.288073546535696,"score_spread":0.2804802507278142,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}