{"id":"W2073332412","doi":"10.1038/ncb2789","title":"TAp73 enhances the pentose phosphate pathway and supports cell proliferation","year":2013,"lang":"en","type":"article","venue":"Nature Cell Biology","topic":"Cancer-related Molecular Pathways","field":"Medicine","cited_by":237,"is_retracted":false,"has_abstract":false,"ca_institutions":"Princess Margaret Cancer Centre","funders":"National Institute of General Medical Sciences; National Cancer Institute","keywords":"Pentose phosphate pathway; Glucose-6-phosphate dehydrogenase; Cell growth; Cell biology; Ribose; Biology; Reactive oxygen species; Downregulation and upregulation; Apoptosis; Dehydrogenase; Glycolysis; Metabolism; Biochemistry; Enzyme; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001655402,0.0001779425,0.0002200703,0.00005686852,0.00009203637,0.0000249804,0.00009407356,0.0005603563,0.0006349687],"category_scores_gemma":[0.00005123134,0.0001092085,0.00006063276,0.0001276332,0.0001301159,0.0000525216,0.00005384143,0.0007242655,0.0001341215],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003328438,"about_ca_system_score_gemma":0.0001108353,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004538324,"about_ca_topic_score_gemma":0.00002274979,"domain_scores_codex":[0.9989552,0.00007837646,0.0002033503,0.0003580435,0.0001105769,0.0002944006],"domain_scores_gemma":[0.999298,0.00005641392,0.0001133192,0.0002997452,0.0001254161,0.0001070639],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005489985,0.00007230562,0.001024158,0.00005817116,0.00001998908,0.00001816111,0.0002935239,0.000001158242,0.983811,0.0001306199,0.005499083,0.009016886],"study_design_scores_gemma":[0.0008817295,0.0003771332,0.001857182,0.00001841793,0.00004579517,0.00004433639,0.00006560989,0.00009706762,0.8994201,0.000261775,0.09679189,0.000138976],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9680729,0.01694618,0.00009087258,0.002126588,0.0006884195,0.001174124,0.00001068027,0.00006337087,0.01082686],"genre_scores_gemma":[0.9936274,0.0007113486,0.0002037564,0.002445794,0.0002151688,0.00008960409,0.0001200274,0.00002055369,0.002566374],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.09129281,"threshold_uncertainty_score":0.6952462,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003536487656341407,"score_gpt":0.2229866864823596,"score_spread":0.2194501988260182,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}