{"id":"W2073337147","doi":"10.1038/tp.2015.11","title":"MicroRNA regulation of central glial cell line-derived neurotrophic factor (GDNF) signalling in depression","year":2015,"lang":"en","type":"article","venue":"Translational Psychiatry","topic":"Neurogenesis and neuroplasticity mechanisms","field":"Neuroscience","cited_by":60,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre; McGill University; Douglas Mental Health University Institute","funders":"Fonds de Recherche du Québec - Santé; Canadian Institutes of Health Research; American Foundation for Suicide Prevention","keywords":"Glial cell line-derived neurotrophic factor; Neurotrophic factors; Gene knockdown; Biology; Endocrinology; GDNF family of ligands; Internal medicine; Cell biology; Neuroscience; Cell culture; Receptor; Medicine; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008924035,0.0001936185,0.0002660354,0.0001434057,0.0001421467,0.0002437348,0.00009753396,0.0002340901,0.0004440482],"category_scores_gemma":[0.0001045082,0.0001087697,0.0001733401,0.00007276685,0.0001695895,0.00009018093,0.0001569696,0.000266916,0.0001776181],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002958231,"about_ca_system_score_gemma":0.0001353846,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001004101,"about_ca_topic_score_gemma":0.001433566,"domain_scores_codex":[0.9999154,0.00001375335,0.000009242329,0.00002281422,0.00001978734,0.00001897135],"domain_scores_gemma":[0.999958,0.000004334395,0.00001545801,0.000002871167,0.00000832517,0.00001087717],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003104116,0.00001529312,0.001118,0.00007176027,0.00001168214,0.000195052,0.00007045725,0.00004599868,0.9944533,0.000141182,0.0001036968,0.003463141],"study_design_scores_gemma":[0.0001237557,0.0007997497,0.2096314,0.00006845095,0.0001533851,0.00246715,0.000322883,0.002151966,0.7725755,0.0004133888,0.01126227,0.00003008272],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9879166,0.008829821,0.001141561,0.0001685142,0.00005543485,0.00002310969,0.0003653329,0.00005257945,0.001447183],"genre_scores_gemma":[0.995048,0.002623574,0.001011049,0.00007082244,0.00001067341,0.00002490242,0.0001882582,0.0000106048,0.001012004],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001004101,"threshold_uncertainty_score":0.002146304,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05290684526907597,"score_gpt":0.2638050364753966,"score_spread":0.2108981912063206,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}