{"id":"W2073343115","doi":"10.1093/nar/gkg437","title":"The C terminus of the human telomerase reverse transcriptase is a determinant of enzyme processivity","year":2003,"lang":"en","type":"article","venue":"Nucleic Acids Research","topic":"Telomeres, Telomerase, and Senescence","field":"Medicine","cited_by":98,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Canadian Institutes of Health Research","keywords":"Processivity; Biology; Telomerase; Telomerase reverse transcriptase; Telomere; Protein subunit; Telomerase RNA component; Molecular biology; Saccharomyces cerevisiae; Reverse transcriptase; C-terminus; Conserved sequence; Biochemistry; Peptide sequence; Enzyme; RNA; DNA; Yeast; DNA polymerase; Amino acid; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002112031,0.0002159081,0.0004503129,0.0001922359,0.0006592384,0.00002986915,0.0006731135,0.0001573647,0.0002979533],"category_scores_gemma":[0.001168112,0.0001197913,0.0002470646,0.001091205,0.001592069,0.0001080134,0.0001026715,0.0007942066,0.00002084841],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009018152,"about_ca_system_score_gemma":0.0005776903,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002621595,"about_ca_topic_score_gemma":0.00005656252,"domain_scores_codex":[0.9962675,0.0005349747,0.0006047886,0.0004118009,0.001469386,0.0007115721],"domain_scores_gemma":[0.9973723,0.0002963846,0.0001706974,0.001300069,0.0006314713,0.0002291316],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005876288,0.001176168,0.06463705,0.001364772,0.0001335819,0.0002668383,0.007075018,4.628793e-7,0.8606637,0.001407802,0.01911243,0.04357458],"study_design_scores_gemma":[0.002257183,0.000729632,0.06083427,0.0005717203,0.00009057359,0.0002055057,0.00237927,0.00006602681,0.8511633,0.000548149,0.08090759,0.0002467617],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9936022,0.0007690942,0.00000732648,0.001154383,0.000109261,0.00087657,0.00004118714,0.00002065087,0.003419332],"genre_scores_gemma":[0.9942416,0.0002193559,0.0001378596,0.000191928,0.00005167269,0.00004423131,0.00000209018,0.00003717342,0.005074083],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06179516,"threshold_uncertainty_score":0.5866046,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05859806649967284,"score_gpt":0.3591600784354533,"score_spread":0.3005620119357805,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}