{"id":"W2073347761","doi":"10.1007/s13238-011-1018-1","title":"Structure and function of WD40 domain proteins","year":2011,"lang":"en","type":"review","venue":"Protein & Cell","topic":"Protein Structure and Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":658,"is_retracted":false,"has_abstract":true,"ca_institutions":"Structural Genomics Consortium; University of Toronto","funders":"Knut och Alice Wallenbergs Stiftelse; Karolinska Institutet; Stiftelsen för Strategisk Forskning; Ontario Genomics Institute; Canadian Institutes of Health Research; Ontario Genomics; Genome Canada; Ontario Innovation Trust; Wellcome Trust; University of Toronto; GlaxoSmithKline","keywords":"EGF-like domain; Cyclic nucleotide-binding domain; Protein domain; Computational biology; HAMP domain; Domain (mathematical analysis); Function (biology); Biology; Protein structure; Binding domain; Cell biology; Genetics; Biochemistry; Peptide sequence; Binding site; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002450132,0.0006240032,0.0007162784,0.00104286,0.0002437069,0.0006308074,0.0005858481,0.0005799123,0.00107328],"category_scores_gemma":[0.0002361282,0.0001822272,0.000238622,0.001106668,0.0003188748,0.000565915,0.0003211067,0.000620075,0.001650782],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006644828,"about_ca_system_score_gemma":0.0006807158,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001038804,"about_ca_topic_score_gemma":0.0006705256,"domain_scores_codex":[0.9999055,0.000009508221,0.00001252728,0.00002278286,0.0000374281,0.00001229408],"domain_scores_gemma":[0.9999371,0.00001540609,0.0000129281,0.000003006703,0.00002387371,0.000007831364],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00009879289,0.00004913173,0.0005652795,0.01057963,0.00006401663,0.0005874783,0.0001039823,0.0008932949,0.04770789,0.008780037,0.01520114,0.9153693],"study_design_scores_gemma":[0.000006986676,0.00005509552,0.001701835,0.0008709238,0.00005488213,0.002764507,0.00004755373,0.0001861816,0.01134336,0.002884931,0.9800647,0.00001908015],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.001024695,0.9960019,0.0006248806,0.0001607624,0.00008677933,0.000004571486,0.00005085517,0.00001575489,0.002029662],"genre_scores_gemma":[0.007547601,0.988191,0.001013947,0.0001254723,0.00009049039,0.00001089398,0.0001644685,0.00000460123,0.002851653],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.00107328,"threshold_uncertainty_score":0.004821241,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009927520008057154,"score_gpt":0.2332912049227119,"score_spread":0.2233636849146547,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}