{"id":"W2073353599","doi":"10.1016/j.bmcl.2009.10.078","title":"Multivalent binding oligomers inhibit HIV Tat–TAR interaction critical for viral replication","year":2009,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":11,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Montréal","funders":"Canadian Institutes of Health Research; National Institutes of Health","keywords":"Chemistry; RNA; In vitro; tar (computing); HIV Long Terminal Repeat; Small molecule; Viral replication; Cell biology; Biochemistry; Computational biology; Combinatorial chemistry; Virology; Virus; Biology; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001775172,0.0003869197,0.0003038771,0.0002560545,0.00037268,0.000594103,0.0002953964,0.0004321692,0.003673612],"category_scores_gemma":[0.0002400104,0.0002777745,0.0002236342,0.0001677831,0.000261037,0.0002263137,0.0003602406,0.0009822751,0.000870311],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005076673,"about_ca_system_score_gemma":0.0002601673,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007230134,"about_ca_topic_score_gemma":0.001228751,"domain_scores_codex":[0.9997807,0.0000431568,0.00001371943,0.0000346852,0.0000425002,0.00008520657],"domain_scores_gemma":[0.9998769,0.00003336495,0.00001878408,0.00002003082,0.00001241655,0.00003845949],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004859765,0.0002247675,0.00015126,0.00003699312,0.00002033015,0.00003199104,0.00002913609,0.0002514259,0.9957064,0.0003943408,0.000256707,0.002410778],"study_design_scores_gemma":[0.00007573589,0.0004749084,0.000756092,0.000006231465,0.00002696205,0.0001327711,0.00002743673,0.001221302,0.994355,0.000130494,0.002785395,0.000007824167],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9934395,0.001168032,0.002060668,0.0001008827,0.00008192628,0.00005044993,0.0001411014,0.000147809,0.00280951],"genre_scores_gemma":[0.9957436,0.0003654281,0.000955714,0.00008419962,0.00001732127,0.00002618029,0.0001832448,0.00002732526,0.002596919],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003673612,"threshold_uncertainty_score":0.01228946,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02012121343237762,"score_gpt":0.3082343173786629,"score_spread":0.2881131039462853,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}