{"id":"W2073354258","doi":"10.1158/1538-7445.am2012-4897","title":"Abstract 4897: Involvement of Akt isoforms in chemoresistance of carcinoma endometrial cells","year":2012,"lang":"en","type":"article","venue":"Cancer Research","topic":"Kruppel-like factors research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université du Québec à Trois-Rivières","funders":"","keywords":"Protein kinase B; AKT2; AKT1; Cancer research; Cisplatin; Cell growth; AKT3; XIAP; Cell culture; Biology; Gene isoform; PI3K/AKT/mTOR pathway; Apoptosis; Chemistry; Cell biology; Signal transduction; Programmed cell death; Caspase; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0018323,0.000133859,0.0002671599,0.0003697028,0.00003441,0.00001077191,0.0005009143,0.0001669589,0.0002923906],"category_scores_gemma":[0.000329395,0.0001200038,0.0000979848,0.0006533213,0.0003284967,0.00001262877,0.0003183374,0.0002861177,0.00001016141],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001787925,"about_ca_system_score_gemma":0.0004775442,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001494379,"about_ca_topic_score_gemma":0.0004495649,"domain_scores_codex":[0.9974978,0.0001198474,0.0004044785,0.0002984754,0.000868884,0.0008105331],"domain_scores_gemma":[0.9986826,0.00009565378,0.000101717,0.0005469611,0.0003917462,0.0001813694],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005146046,0.0002018377,0.1290956,0.0002368256,0.00002697678,0.00000161442,0.0001406308,0.000008054318,0.8668592,0.00003453502,0.001737831,0.001142357],"study_design_scores_gemma":[0.00110483,0.000192973,0.07152876,0.00004040034,0.000002243995,2.944165e-7,0.0002127621,0.000001561013,0.9234303,0.00002167213,0.003360526,0.0001037199],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9944231,0.003703735,0.000008659263,0.00004845672,0.0001681045,0.0004492198,0.00008251252,0.000002364628,0.001113882],"genre_scores_gemma":[0.9983626,0.0006540029,0.00006612476,0.000009485691,0.0003042067,0.00009730317,0.00003045001,0.00002650728,0.0004492932],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0575668,"threshold_uncertainty_score":0.4893611,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07482913688226994,"score_gpt":0.3874890555573671,"score_spread":0.3126599186750971,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}