{"id":"W2073354537","doi":"10.1038/npp.2015.40","title":"Effect of Brain CYP2B Inhibition on Brain Nicotine Levels and Nicotine Self-Administration","year":2015,"lang":"en","type":"article","venue":"Neuropsychopharmacology","topic":"Nicotinic Acetylcholine Receptors Study","field":"Biochemistry, Genetics and Molecular Biology","cited_by":27,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto; Centre for Addiction and Mental Health","funders":"National Institute on Drug Abuse; Ontario Ministry of Research and Innovation; Campbell Family Mental Health Research Institute; Canadian Institutes of Health Research; Centre for Addiction and Mental Health Foundation","keywords":"Nicotine; Pharmacology; Microdialysis; Toxicity; Xanthate; Chemistry; In vivo; Self-administration; Medicine; Central nervous system; Endocrinology; Internal medicine; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004849945,0.001119462,0.001379025,0.0004120554,0.0005729123,0.0007041657,0.0009045911,0.0009646004,0.006840758],"category_scores_gemma":[0.0009789305,0.0006959557,0.0006710153,0.0004835918,0.001452699,0.001160442,0.0004795632,0.002558317,0.0009471953],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009028272,"about_ca_system_score_gemma":0.001421194,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004686909,"about_ca_topic_score_gemma":0.007100526,"domain_scores_codex":[0.9994381,0.0001271316,0.0000390395,0.0001282338,0.00009320664,0.0001743119],"domain_scores_gemma":[0.9990581,0.000239444,0.0001120287,0.0002056944,0.00008613386,0.000298651],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.2700394,0.007853216,0.00382986,0.0001560539,0.0004175026,0.0003653039,0.0003062345,0.0007590036,0.6944929,0.0008190874,0.001136323,0.01982511],"study_design_scores_gemma":[0.001942968,0.0225668,0.02226354,0.00001555835,0.0004429426,0.0003338319,0.0001613955,0.004038148,0.9447665,0.0003735005,0.003041176,0.00005362395],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.99575,0.0005809049,0.0006317379,0.0001866979,0.0001217448,0.0001026695,0.0005728737,0.00009012852,0.001963172],"genre_scores_gemma":[0.9859052,0.000643222,0.00104694,0.0001324359,0.0001218231,0.0002273969,0.001138489,0.00009375525,0.01069065],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006840758,"threshold_uncertainty_score":0.02288467,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01312886406495539,"score_gpt":0.3252274021317746,"score_spread":0.3120985380668193,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}