{"id":"W2073394972","doi":"10.1097/00000542-200109000-00009","title":"North American Malignant Hyperthermia Population","year":2001,"lang":"en","type":"article","venue":"Anesthesiology","topic":"Ion channel regulation and function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":57,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Uniformed Services University of the Health Sciences","keywords":"RYR1; Malignant hyperthermia; Genetics; Skeletal muscle; Ryanodine receptor; Medicine; Genotype; Restriction fragment length polymorphism; Compound heterozygosity; Population; Gene; Exon; Molecular biology; Mutation; Biology; Pathology; Internal medicine; Receptor","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007871918,0.0001889799,0.0001361129,0.0003632717,0.0005307434,0.0001503718,0.0001859945,0.0001554674,0.007684629],"category_scores_gemma":[0.0002521843,0.00005442523,0.0000798382,0.0005220115,0.0001340544,0.0001430316,0.0002720257,0.0001753123,0.0009575579],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002875523,"about_ca_system_score_gemma":0.0003623104,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01717208,"about_ca_topic_score_gemma":0.01807281,"domain_scores_codex":[0.9999026,0.00002081063,0.000004559206,0.0000238555,0.00002309052,0.00002504187],"domain_scores_gemma":[0.999884,0.000009063464,0.00003048912,0.000005081496,0.00003316985,0.00003819316],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0002332329,0.0001313555,0.9315355,0.0001303154,0.00007056681,0.002198416,0.001157256,0.0001823604,0.004434344,0.000556081,0.02047121,0.0388993],"study_design_scores_gemma":[0.00002694023,0.0001069565,0.9664393,0.00003888991,0.0000488243,0.003854731,0.0009621248,0.0002777226,0.0003308478,0.0001942874,0.0277113,0.000008146514],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9748958,0.002044507,0.0006366249,0.001075819,0.0000973385,0.00009086246,0.001885948,0.0001056006,0.01916733],"genre_scores_gemma":[0.9925132,0.00122052,0.0002772952,0.0006140797,0.0001035005,0.000113999,0.00112236,0.00000865845,0.004026289],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01717208,"threshold_uncertainty_score":0.03414422,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01150932860684816,"score_gpt":0.2319762213367765,"score_spread":0.2204668927299283,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}