{"id":"W2073394972","doi":"10.1097/00000542-200109000-00009","title":"North American Malignant Hyperthermia Population","year":2001,"lang":"en","type":"article","venue":"Anesthesiology","topic":"Ion channel regulation and function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":57,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Uniformed Services University of the Health Sciences","keywords":"RYR1; Malignant hyperthermia; Genetics; Skeletal muscle; Ryanodine receptor; Medicine; Genotype; Restriction fragment length polymorphism; Compound heterozygosity; Population; Gene; Exon; Molecular biology; Mutation; Biology; Pathology; Internal medicine; Receptor","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00005551658,0.00009185333,0.0001039062,0.00003926037,0.00006302877,0.000005221576,0.0000679545,0.00006445235,0.00003430493],"category_scores_gemma":[0.00002480346,0.00007923919,0.00004686826,0.0001082482,0.00005707339,0.000002344325,0.00001668045,0.00003401616,0.0000562161],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000007411269,"about_ca_system_score_gemma":0.00001112764,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001125591,"about_ca_topic_score_gemma":0.0002552594,"domain_scores_codex":[0.9993801,0.00006262815,0.0001243909,0.0002199425,0.0000500943,0.0001628527],"domain_scores_gemma":[0.9996628,0.000006563084,0.00006517853,0.0001819751,0.00003822656,0.00004524316],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0001499729,0.00003057119,0.9662505,0.000001611984,0.00001130975,0.000009966765,0.00002441862,0.0003414836,0.008277114,0.00006356909,0.0007053055,0.02413418],"study_design_scores_gemma":[0.0001469852,0.0003183559,0.9006241,9.475082e-7,0.000004589961,0.0001222586,0.0000256847,0.0001396301,0.0007935144,0.00003092609,0.09768434,0.000108701],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9990891,0.00005665156,0.0002283333,0.0001403817,0.0001463502,0.00007193092,9.211274e-7,0.00002253264,0.0002437735],"genre_scores_gemma":[0.9973662,0.0001229922,0.0001049566,0.001010817,0.0004141287,0.00001141257,0.0002811133,0.00001386119,0.0006745555],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.09697903,"threshold_uncertainty_score":0.323128,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01150932860684816,"score_gpt":0.2319762213367765,"score_spread":0.2204668927299283,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}