{"id":"W2073400944","doi":"10.1074/jbc.m111.312660","title":"Critical Role for Antiapoptotic Bcl-xL and Mcl-1 in Human Macrophage Survival and Cellular IAP1/2 (cIAP1/2) in Resistance to HIV-Vpr-induced Apoptosis","year":2012,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":81,"is_retracted":false,"has_abstract":true,"ca_institutions":"Children's Hospital of Eastern Ontario; University of Ottawa","funders":"Canadian Institutes of Health Research","keywords":"Apoptosis; Cell biology; Inhibitor of apoptosis; Biology; Bcl-xL; Inhibitor of apoptosis domain; XIAP; U937 cell; Small interfering RNA; Caspase; Bcl-2 family; Multinucleate; Programmed cell death; Cell culture; Transfection; Biochemistry; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002122548,0.0003080154,0.0001685033,0.0003653791,0.0002408876,0.0004146613,0.0002064311,0.0003344982,0.001667422],"category_scores_gemma":[0.000182782,0.0001369819,0.0001722135,0.0001533941,0.0002115789,0.0003077836,0.0002549534,0.0003848398,0.0004607445],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003383025,"about_ca_system_score_gemma":0.0002223733,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002237897,"about_ca_topic_score_gemma":0.000158432,"domain_scores_codex":[0.9998301,0.00003522798,0.00001610719,0.00003045868,0.00003406373,0.00005395931],"domain_scores_gemma":[0.9998446,0.00002381341,0.00004190446,0.00001425873,0.0000297396,0.00004556445],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004250176,0.00004460225,0.0007013018,0.00006822781,0.000006560086,0.0001541537,0.00003885098,0.00004474531,0.9958038,0.0002398213,0.00006156883,0.002411477],"study_design_scores_gemma":[0.0000751646,0.0004240695,0.0180171,0.00001952519,0.00003022117,0.00178173,0.0001166142,0.0009817882,0.9725476,0.0002341325,0.005762862,0.00000926049],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9878587,0.008499762,0.001960129,0.000197829,0.00002847242,0.00002862889,0.0002305372,0.00007357029,0.001122558],"genre_scores_gemma":[0.996723,0.0009530157,0.0008273479,0.00004897311,0.00001069733,0.00003115778,0.0002355426,0.000005248176,0.001165085],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001667422,"threshold_uncertainty_score":0.005578041,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02688740226421146,"score_gpt":0.2969233131662764,"score_spread":0.270035910902065,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}