{"id":"W2073400944","doi":"10.1074/jbc.m111.312660","title":"Critical Role for Antiapoptotic Bcl-xL and Mcl-1 in Human Macrophage Survival and Cellular IAP1/2 (cIAP1/2) in Resistance to HIV-Vpr-induced Apoptosis","year":2012,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":81,"is_retracted":false,"has_abstract":true,"ca_institutions":"Children's Hospital of Eastern Ontario; University of Ottawa","funders":"Canadian Institutes of Health Research","keywords":"Apoptosis; Cell biology; Inhibitor of apoptosis; Biology; Bcl-xL; Inhibitor of apoptosis domain; XIAP; U937 cell; Small interfering RNA; Caspase; Bcl-2 family; Multinucleate; Programmed cell death; Cell culture; Transfection; Biochemistry; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006780672,0.0001759206,0.0004479312,0.0000702597,0.00009581246,0.00002024027,0.0001501647,0.0003255202,0.0001291127],"category_scores_gemma":[0.0006244197,0.0001291042,0.00007565058,0.0001019453,0.0001859871,0.00007675691,0.00009418962,0.0004395951,0.00001178997],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007313241,"about_ca_system_score_gemma":0.00002824845,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000008994689,"about_ca_topic_score_gemma":0.00000626635,"domain_scores_codex":[0.9985532,0.0001494141,0.0004334814,0.00022731,0.00005509105,0.0005815557],"domain_scores_gemma":[0.9991709,0.0003949048,0.00008277727,0.0001140264,0.00006914858,0.0001682699],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004420735,0.0003742301,0.043758,0.00005865889,0.00003926495,0.00002066255,0.00009236651,1.656026e-7,0.9544891,0.00007468166,0.0001761488,0.0004746213],"study_design_scores_gemma":[0.002207058,0.0003616613,0.0383996,0.00008371624,0.00001940026,0.00004841305,0.0003868179,4.007228e-7,0.9563,0.0002591842,0.00176471,0.0001690858],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9938681,0.004835988,0.00003085542,0.0005213281,0.00007276149,0.0001488331,0.00005334992,0.000006235981,0.0004626004],"genre_scores_gemma":[0.9992129,0.0001059266,0.0002868339,0.00003521577,0.00008294392,0.00001567695,0.00002530724,0.000008608005,0.0002265866],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005358404,"threshold_uncertainty_score":0.5264719,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02688740226421146,"score_gpt":0.2969233131662764,"score_spread":0.270035910902065,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}