{"id":"W2073424135","doi":"10.1074/jbc.m303180200","title":"Activation of the Rap GTPases in B Lymphocytes Modulates B Cell Antigen Receptor-induced Activation of Akt but Has No Effect on MAPK Activation","year":2003,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"PI3K/AKT/mTOR signaling in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":54,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"","keywords":"Protein kinase B; PI3K/AKT/mTOR pathway; MAPK/ERK pathway; Cell biology; breakpoint cluster region; Phosphorylation; Signal transduction; B-cell receptor; GTPase; Biology; Small GTPase; Kinase; Cancer research; Chemistry; B cell; Receptor; Immunology; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001641626,0.0003815737,0.0002051757,0.0002205132,0.0001971425,0.0003429747,0.0002258205,0.0003039571,0.002026184],"category_scores_gemma":[0.0001394176,0.000195228,0.0002730229,0.0001818349,0.0002436413,0.0002182666,0.0001977551,0.001029112,0.0007240812],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002569254,"about_ca_system_score_gemma":0.0001793606,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002940639,"about_ca_topic_score_gemma":0.0004728067,"domain_scores_codex":[0.9996548,0.0001011004,0.0000296539,0.00004341695,0.00006864061,0.0001023771],"domain_scores_gemma":[0.999872,0.00002618325,0.00002604392,0.00002086277,0.00001259564,0.00004224463],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002243756,0.00006778792,0.00007308842,0.00003617125,0.000006279389,0.00003694063,0.00001129111,0.00004382527,0.9983757,0.0001207953,0.00006740152,0.0009364649],"study_design_scores_gemma":[0.00003505367,0.0003721349,0.002717431,0.000006850126,0.00001949219,0.0001864523,0.00001931333,0.0005312649,0.9932135,0.0000463078,0.002848153,0.000003881681],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9950057,0.001778546,0.0007551718,0.0001664907,0.00004894999,0.00001882949,0.0003114421,0.00005459142,0.001860367],"genre_scores_gemma":[0.9932887,0.001188409,0.001398331,0.00007515181,0.00002915018,0.00007506305,0.0007023398,0.0000223829,0.003220502],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002026184,"threshold_uncertainty_score":0.00677824,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02290860948296883,"score_gpt":0.2499277694221493,"score_spread":0.2270191599391805,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}