{"id":"W2073433364","doi":"10.1016/s1074-5521(02)00245-4","title":"Analysis of the π-π Stacking Interactions between the Aminoglycoside Antibiotic Kinase APH(3′)-IIIa and Its Nucleotide Ligands","year":2002,"lang":"en","type":"article","venue":"Chemistry & Biology","topic":"RNA and protein synthesis mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":96,"is_retracted":false,"has_abstract":false,"ca_institutions":"McMaster University","funders":"National Center for Research Resources; U.S. Public Health Service","keywords":"Stacking; Nucleotide; Stereochemistry; Phosphotransferase; Binding site; Ring (chemistry); Electrostatics; Adenine nucleotide; Static electricity; Mutant; Enzyme; Biochemistry; Biology; Chemistry; Crystallography; Biophysics; Physics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001620068,0.0001700333,0.0002585749,0.00003155188,0.0001727095,0.00001716982,0.0003616228,0.0001718852,0.0001310771],"category_scores_gemma":[0.0001765032,0.0001088466,0.0001977098,0.0002622696,0.0001847662,0.000003639753,0.0002138762,0.0001329723,0.000003755218],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00000961294,"about_ca_system_score_gemma":0.00001258184,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001276315,"about_ca_topic_score_gemma":0.000009146001,"domain_scores_codex":[0.9990329,0.00006637625,0.0002650098,0.0003416977,0.00006699951,0.00022707],"domain_scores_gemma":[0.9991065,0.00007339277,0.0001943821,0.0005073474,0.00006204446,0.00005634117],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000008250251,0.0000226682,0.02025047,0.00001906062,0.0004280151,6.532863e-7,0.00004888839,0.000006180178,0.9770168,0.00002000369,0.00007656585,0.002102427],"study_design_scores_gemma":[0.0001282401,0.00003487772,0.007912383,0.00001744996,0.0004049896,0.000007409964,0.00006148696,0.0001501387,0.9877405,0.00003761244,0.003374289,0.0001306303],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.997043,0.00139573,0.00008850659,0.0003957876,0.00007260268,0.0001136987,0.00006819402,0.000008855278,0.0008136446],"genre_scores_gemma":[0.9987742,0.0002748417,0.00003037196,0.0001111043,0.000159283,0.000007084745,0.00004679853,0.00001353673,0.0005827276],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01233808,"threshold_uncertainty_score":0.4438634,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01868620643379279,"score_gpt":0.2510518772502112,"score_spread":0.2323656708164184,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}