{"id":"W2073437817","doi":"10.1016/j.jim.2003.07.011","title":"Selection of hapten-specific single-domain antibodies from a non-immunized llama ribosome display library","year":2003,"lang":"en","type":"article","venue":"Journal of Immunological Methods","topic":"Monoclonal and Polyclonal Antibodies Research","field":"Medicine","cited_by":118,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Guelph","funders":"","keywords":"Panning (audio); Biology; Phage display; Molecular biology; Complementarity determining region; Ribosome; Affinity maturation; Genomic library; Computational biology; Genetics; Antibody; Peptide sequence; Immunoglobulin light chain; Gene; RNA","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003380713,0.0005095843,0.0006932757,0.0003714292,0.0002781779,0.0004872736,0.0004275664,0.0003745642,0.00254218],"category_scores_gemma":[0.0003603653,0.0002790036,0.0003796231,0.0004124604,0.0001560076,0.0001691323,0.00056174,0.00091493,0.001326995],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002902699,"about_ca_system_score_gemma":0.0001650094,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005944159,"about_ca_topic_score_gemma":0.001108247,"domain_scores_codex":[0.9996824,0.00006238068,0.00001760923,0.00005912074,0.00008117599,0.00009734237],"domain_scores_gemma":[0.9997696,0.00009255911,0.00002194293,0.00003469474,0.00003292758,0.00004834588],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005626318,0.00003039128,0.0001170753,0.00001185472,0.000003978818,0.00002804749,0.00001313542,0.00005984423,0.9986724,0.00003283318,0.00004675364,0.0009274794],"study_design_scores_gemma":[0.00001360072,0.000144372,0.001413768,0.000002374592,0.00001701255,0.0001330237,0.00001603843,0.0008812232,0.996312,0.00001353205,0.001049368,0.000003617921],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9789037,0.0003231834,0.0167303,0.0001394784,0.0000427701,0.0001442081,0.0003457927,0.000280366,0.003090231],"genre_scores_gemma":[0.9781461,0.0003893641,0.0104777,0.0001887894,0.00002673176,0.000118246,0.001625847,0.0001829168,0.008844408],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00254218,"threshold_uncertainty_score":0.008504391,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05230081675302463,"score_gpt":0.358106911827363,"score_spread":0.3058060950743384,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}