{"id":"W2073469088","doi":"10.1021/bi501350j","title":"Redox State of Flavin Adenine Dinucleotide Drives Substrate Binding and Product Release in <i>Escherichia coli</i> Succinate Dehydrogenase","year":2015,"lang":"en","type":"article","venue":"Biochemistry","topic":"Amino Acid Enzymes and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":29,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"National Institute of General Medical Sciences; Canadian Institutes of Health Research; U.S. Department of Veterans Affairs","keywords":"SDHA; Fumarate reductase; Cofactor; Succinate dehydrogenase; Flavin adenine dinucleotide; Chemistry; Flavoprotein; Flavin group; Stereochemistry; Substrate (aquarium); Active site; Biochemistry; Enzyme; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001304926,0.0001550431,0.0001707632,0.00005690455,0.00007858478,0.0004403436,0.0002071668,0.0001898282,0.0003005716],"category_scores_gemma":[0.0002778415,0.0001183618,0.0001207963,0.00009848002,0.0001850415,0.0001471771,0.0001667292,0.0002606646,0.0001676217],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003228813,"about_ca_system_score_gemma":0.0001376806,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001647952,"about_ca_topic_score_gemma":0.001285424,"domain_scores_codex":[0.9998442,0.00003025137,0.00001286118,0.00003053877,0.00004985682,0.00003226937],"domain_scores_gemma":[0.9998894,0.00003703908,0.00002103575,0.00001356945,0.0000193674,0.00001975572],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007591583,0.00002210389,0.0006208432,0.00001547799,0.000002830159,0.00003702521,0.00002377697,0.0001290958,0.9979578,0.00008348242,0.00002335407,0.001008202],"study_design_scores_gemma":[0.000006352928,0.00007413615,0.003559771,0.000002360218,0.000003699377,0.00006299844,0.00005623235,0.002569701,0.993214,0.0000371627,0.0004088728,0.000004662046],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.998657,0.00007859588,0.0008724893,0.00002810929,0.000004206584,0.000004081354,0.0000482373,0.00002094596,0.0002862669],"genre_scores_gemma":[0.9989737,0.00005515661,0.0005943548,0.00001241409,8.637837e-7,0.000002481381,0.00006462683,0.000009990949,0.0002863525],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001647952,"threshold_uncertainty_score":0.003276706,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00839709272190213,"score_gpt":0.2271908416912692,"score_spread":0.2187937489693671,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}