{"id":"W2073469088","doi":"10.1021/bi501350j","title":"Redox State of Flavin Adenine Dinucleotide Drives Substrate Binding and Product Release in <i>Escherichia coli</i> Succinate Dehydrogenase","year":2015,"lang":"en","type":"article","venue":"Biochemistry","topic":"Amino Acid Enzymes and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":29,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"National Institute of General Medical Sciences; Canadian Institutes of Health Research; U.S. Department of Veterans Affairs","keywords":"SDHA; Fumarate reductase; Cofactor; Succinate dehydrogenase; Flavin adenine dinucleotide; Chemistry; Flavoprotein; Flavin group; Stereochemistry; Substrate (aquarium); Active site; Biochemistry; Enzyme; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002636427,0.0002381795,0.0002636138,0.0000430978,0.0000313502,0.00001908335,0.0001812588,0.0001112712,0.000004580627],"category_scores_gemma":[0.0001631295,0.000237499,0.00005937248,0.0001726297,0.0001589509,0.000009180389,0.0001395666,0.0001357634,0.000002826542],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001883122,"about_ca_system_score_gemma":0.0001786888,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004708463,"about_ca_topic_score_gemma":0.00002737693,"domain_scores_codex":[0.9986249,0.0000432448,0.0003493007,0.0004965164,0.0001516409,0.0003344042],"domain_scores_gemma":[0.9990936,0.00000673321,0.0001658458,0.0003921731,0.00009589571,0.000245768],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001651161,0.00007399836,0.005838708,0.00008010323,0.00002708177,0.00002340621,0.00007948767,0.00003970224,0.9922696,0.000005649027,0.0008066822,0.0005904746],"study_design_scores_gemma":[0.001041401,0.00007818028,0.00306765,0.00004019011,0.00002075904,0.00002263347,0.0001197831,0.00005278809,0.9925025,0.00002355522,0.002762928,0.0002677099],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9938812,0.005281583,0.0000145289,0.00008115578,0.00007759706,0.0001613785,0.00007986845,0.00001475637,0.0004078851],"genre_scores_gemma":[0.997026,0.0005840941,0.0006985787,0.00004882373,0.0001340166,0.00001542513,0.0001241255,0.00003301046,0.001335979],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00469749,"threshold_uncertainty_score":0.9684926,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00839709272190213,"score_gpt":0.2271908416912692,"score_spread":0.2187937489693671,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}