{"id":"W2073496185","doi":"10.1074/jbc.m208307200","title":"An Extremely Potent Inhibitor of Xanthine Oxidoreductase","year":2003,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Gout, Hyperuricemia, Uric Acid","field":"Medicine","cited_by":424,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network; Ontario Institute for Cancer Research; University of Toronto","funders":"","keywords":"Chemistry; Oxidoreductase; Xanthine; Active site; Titration; Enzyme; Substrate (aquarium); Pterin; Xanthine dehydrogenase; Kinetics; Stereochemistry; Steady state (chemistry); Cofactor; Crystallography; Inorganic chemistry; Biochemistry; Xanthine oxidase; Organic chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005094242,0.0001739438,0.0005265572,0.00003614391,0.00002783536,0.000007150774,0.0001706754,0.0002742239,0.0006314772],"category_scores_gemma":[0.0009597138,0.0001078578,0.0002315922,0.0001573723,0.0001711134,0.00006099215,0.00002356991,0.0004996356,0.000004435813],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007614616,"about_ca_system_score_gemma":0.0001534706,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000001730792,"about_ca_topic_score_gemma":2.575482e-8,"domain_scores_codex":[0.9984795,0.00005393119,0.0007064125,0.0001844666,0.0003468004,0.0002288806],"domain_scores_gemma":[0.9985617,0.00005816206,0.0004894191,0.0002711248,0.0002610303,0.0003585234],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002854534,0.0007434565,0.008727994,0.00006437206,0.000078719,0.0003136416,0.00003568037,0.000005229651,0.9881591,0.000009081406,0.0008143084,0.0007629179],"study_design_scores_gemma":[0.00146238,0.0008488012,0.004840043,0.00009773726,0.0001191131,0.003242688,0.000317337,0.000009963546,0.9859051,0.000158127,0.002868955,0.0001297912],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9958743,0.001480425,0.00009426396,0.0003222953,0.0001176825,0.00006503581,0.000008686842,0.0000142109,0.002023063],"genre_scores_gemma":[0.994365,0.0001459289,0.004697631,0.000175636,0.0004665096,0.000001016191,0.00000893775,0.00001119215,0.0001281258],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004603367,"threshold_uncertainty_score":0.6914232,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03100043647398893,"score_gpt":0.2775575214246797,"score_spread":0.2465570849506907,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}