{"id":"W2073496185","doi":"10.1074/jbc.m208307200","title":"An Extremely Potent Inhibitor of Xanthine Oxidoreductase","year":2003,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Gout, Hyperuricemia, Uric Acid","field":"Medicine","cited_by":424,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network; Ontario Institute for Cancer Research; University of Toronto","funders":"","keywords":"Chemistry; Oxidoreductase; Xanthine; Active site; Titration; Enzyme; Substrate (aquarium); Pterin; Xanthine dehydrogenase; Kinetics; Stereochemistry; Steady state (chemistry); Cofactor; Crystallography; Inorganic chemistry; Biochemistry; Xanthine oxidase; Organic chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001458862,0.0004703175,0.0003944979,0.0001629766,0.00009258953,0.0002389514,0.0002721751,0.0002732273,0.0009232704],"category_scores_gemma":[0.0001301643,0.0001258506,0.0001821992,0.0002051535,0.0001197213,0.0001185367,0.0002404864,0.0005779036,0.0004480031],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001986852,"about_ca_system_score_gemma":0.0001934665,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005357147,"about_ca_topic_score_gemma":0.0008947733,"domain_scores_codex":[0.9998226,0.00002661649,0.00001297847,0.00002958306,0.00005924215,0.00004900585],"domain_scores_gemma":[0.999926,0.00001335103,0.00001743117,0.000006530746,0.0000118148,0.00002498592],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001095369,0.00004773301,0.0001628772,0.00007238102,0.00001462561,0.0000525893,0.000008546623,0.0001263166,0.9932603,0.0001023417,0.0001340764,0.00590855],"study_design_scores_gemma":[0.00006384227,0.001007363,0.002637238,0.000008014762,0.0000259939,0.0006181167,0.000006764029,0.001056512,0.9860175,0.0000286716,0.008522388,0.000007573612],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9420734,0.02560234,0.02379879,0.0002176773,0.0001541223,0.0001744069,0.0008588655,0.0004829134,0.006637476],"genre_scores_gemma":[0.9755653,0.008064163,0.006918136,0.0001181402,0.00004527195,0.0001139752,0.001921406,0.00003688947,0.007216701],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009232704,"threshold_uncertainty_score":0.003088653,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03100043647398893,"score_gpt":0.2775575214246797,"score_spread":0.2465570849506907,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}