{"id":"W2073517330","doi":"10.1155/2014/931756","title":"Clicked Cinnamic/Caffeic Esters and Amides as Radical Scavengers and 5-Lipoxygenase Inhibitors","year":2014,"lang":"en","type":"article","venue":"International Journal of Medicinal Chemistry","topic":"Click Chemistry and Applications","field":"Chemistry","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; Université de Moncton","funders":"Natural Sciences and Engineering Research Council of Canada; Canada Research Chairs; New Brunswick Innovation Foundation; Canada Foundation for Innovation; Fondation de la recherche en santé du Nouveau-Brunswick; Université de Moncton","keywords":"Zileuton; Chemistry; Caffeic acid; Cinnamic acid; Arachidonate 5-lipoxygenase; Lipoxygenase; Stereochemistry; Cycloaddition; Enzyme; Biochemistry; Arachidonic acid; Antioxidant; Catalysis","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000353548,0.0002107164,0.0002854089,0.00004812367,0.00007513557,0.00006206376,0.0003847925,0.000170554,0.0004012877],"category_scores_gemma":[0.0006127574,0.000191846,0.0001020782,0.00005830567,0.0004404708,0.0001206906,0.0000992081,0.0005122959,0.00000392565],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009416103,"about_ca_system_score_gemma":0.00008533065,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001495116,"about_ca_topic_score_gemma":8.364618e-7,"domain_scores_codex":[0.998295,0.00001388846,0.000595336,0.0002564505,0.0006458376,0.0001934844],"domain_scores_gemma":[0.9985051,0.0003005332,0.0004328252,0.0001680938,0.0002145822,0.0003788599],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002029929,0.0001101681,0.002852855,0.0001675133,0.0001831245,0.0001016103,0.0002483045,0.000008782847,0.9771897,0.0001364724,0.001313096,0.01748538],"study_design_scores_gemma":[0.002779208,0.00005134953,0.000489691,0.0006921813,0.0001224541,0.004542094,0.0009513249,0.0004737838,0.9531857,0.001327256,0.03507148,0.0003134607],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9894303,0.0004602074,0.00009241386,0.003937184,0.0001388643,0.00002179858,0.00001150174,0.00002168639,0.005886061],"genre_scores_gemma":[0.9968299,0.0003270457,0.0002068447,0.0003247404,0.001704167,0.000004281601,0.00002272955,0.00001952678,0.0005607407],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03375839,"threshold_uncertainty_score":0.7823251,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005726429002386803,"score_gpt":0.2565072212801021,"score_spread":0.2507807922777153,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}