{"id":"W2073518075","doi":"10.1371/journal.pntd.0000441","title":"Leishmania infantum Amastigotes Enhance HIV-1 Production in Cocultures of Human Dendritic Cells and CD4+ T Cells by Inducing Secretion of IL-6 and TNF-α","year":2009,"lang":"en","type":"article","venue":"PLoS neglected tropical diseases","topic":"Research on Leishmaniasis Studies","field":"Medicine","cited_by":32,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre hospitalier de l'Université Laval","funders":"Canadian Institutes of Health Research; Fonds Québécois de la Recherche sur la Nature et les Technologies","keywords":"Leishmania infantum; Leishmania; Amastigote; Biology; Secretion; Dendritic cell; Chemokine; Virology; Macrophage; Immunology; Tumor necrosis factor alpha; Immune system; Cell biology; Visceral leishmaniasis; Leishmaniasis; In vitro; Parasite hosting","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000109123,0.0002063261,0.0005553631,0.0001959054,0.00008741154,0.00002314705,0.00007239524,0.00009104396,0.00002390833],"category_scores_gemma":[0.0007215926,0.0001786665,0.00005067144,0.0003413845,0.0003522125,0.0001623316,0.00005226811,0.0002481029,0.000001339547],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004844827,"about_ca_system_score_gemma":0.00004346523,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004910089,"about_ca_topic_score_gemma":0.00003085264,"domain_scores_codex":[0.9982451,0.0001362379,0.0004431504,0.0004403008,0.0004274373,0.0003078214],"domain_scores_gemma":[0.9991083,0.000133049,0.000131859,0.0002050342,0.0002323715,0.0001894013],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0002341891,0.0007684661,0.03531564,0.0006024827,0.00005964556,0.00001258833,0.0003238112,0.000002336745,0.9608827,0.00005109395,0.000951846,0.0007952483],"study_design_scores_gemma":[0.0005898607,0.0005994682,0.5879353,0.000513895,0.0001007795,0.000002552617,0.000112456,0.00005406113,0.4098231,0.0001598625,0.00001201983,0.00009667393],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9961847,0.00239026,0.00001387201,0.0006111546,0.00002530747,0.0005948165,0.00007680841,0.00004529947,0.00005777901],"genre_scores_gemma":[0.9985723,0.0009837504,0.0001600919,0.00004729999,0.00008134547,0.00002355143,0.00004756863,0.00001574581,0.00006829717],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5526197,"threshold_uncertainty_score":0.7285807,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0115455572635187,"score_gpt":0.2656292840430423,"score_spread":0.2540837267795236,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}