{"id":"W2073523050","doi":"10.1089/08892220050140964","title":"Mutations in the HIV Type 1 Integrase of Patients Receiving Long-Term Dideoxynucleoside Therapy Do Not Confer Resistance to Zidovudine","year":2000,"lang":"en","type":"article","venue":"AIDS Research and Human Retroviruses","topic":"HIV/AIDS drug development and treatment","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Hospital","funders":"National Institutes of Health","keywords":"Integrase; Zidovudine; Integrases; Virology; Biology; Integrase inhibitor; Mutation; Genetics; Lentivirus; Mutant; Recombinant DNA; Resistance mutation; Virus; Reverse transcriptase; Gene; Human immunodeficiency virus (HIV); RNA; Antiretroviral therapy; Viral disease; Viral load","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0005970128,0.0001410992,0.0002562214,0.0003615083,0.000218711,0.00006789948,0.0001647894,0.00004959834,0.0009165707],"category_scores_gemma":[0.0002239655,0.00009099697,0.00003960853,0.0005682725,0.0002252499,0.00009746498,0.00003597452,0.0002749104,0.0001037481],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000796932,"about_ca_system_score_gemma":0.00009401709,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008092404,"about_ca_topic_score_gemma":0.0006876863,"domain_scores_codex":[0.9982859,0.0001718281,0.0003059063,0.0002829564,0.0005893587,0.0003640456],"domain_scores_gemma":[0.9989101,0.0003088057,0.00003403349,0.000325907,0.0002835353,0.0001375666],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0007825078,0.0005187729,0.9830856,0.0000388075,0.00007261461,0.00004457496,0.002902896,1.526018e-7,0.0006946406,0.0005675955,0.003807001,0.007484787],"study_design_scores_gemma":[0.001768476,0.0009453724,0.9898396,0.0002381017,0.00001425766,0.000001126365,0.000270885,1.737009e-7,0.00192583,0.0002009677,0.004702363,0.00009281399],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9938788,0.0002625877,0.000001123774,0.0009944368,0.00001241988,0.0006666851,0.00002319462,0.00001433291,0.004146348],"genre_scores_gemma":[0.9857889,0.0005236331,0.0002085336,0.0002231988,0.00003706514,0.00005893303,0.0000756537,0.00001897346,0.01306514],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008918794,"threshold_uncertainty_score":0.9999967,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07307505761967352,"score_gpt":0.3759893807946429,"score_spread":0.3029143231749694,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}