{"id":"W2073537557","doi":"10.1007/s10875-011-9549-z","title":"A Distinct Role of CD4+ Th17- and Th17-Stimulated CD8+ CTL in the Pathogenesis of Type 1 Diabetes and Experimental Autoimmune Encephalomyelitis","year":2011,"lang":"en","type":"article","venue":"Journal of Clinical Immunology","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":31,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Saskatchewan; Saskatchewan Cancer Agency","funders":"National Eye Institute; Canadian Institutes of Health Research","keywords":"Experimental autoimmune encephalomyelitis; Cytotoxic T cell; Myelin oligodendrocyte glycoprotein; Immunology; RAR-related orphan receptor gamma; CD8; Pathogenesis; Biology; Autoimmunity; CTL*; Immune system; In vitro; FOXP3","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006951778,0.0005539963,0.0004773276,0.0006895806,0.0002849001,0.0006966249,0.0004417637,0.0008101522,0.001720418],"category_scores_gemma":[0.0004387403,0.0002755404,0.0003917069,0.0001649338,0.0006567414,0.0006641712,0.0004525949,0.001241338,0.00035578],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003111446,"about_ca_system_score_gemma":0.0003245955,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001613632,"about_ca_topic_score_gemma":0.0001894701,"domain_scores_codex":[0.9996554,0.00009515534,0.00002956317,0.00004415296,0.00004430582,0.0001313944],"domain_scores_gemma":[0.9996878,0.00007514826,0.00005342437,0.00005551855,0.00004136947,0.00008678863],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.008826687,0.0006701958,0.0272723,0.0006638746,0.00009837293,0.002871349,0.0003760402,0.0005202236,0.8919538,0.004535654,0.0005197658,0.0616918],"study_design_scores_gemma":[0.003661528,0.01114366,0.3877672,0.0008230124,0.001034521,0.03027831,0.002148727,0.009394738,0.5093836,0.01785605,0.02638301,0.0001256125],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9896017,0.006832553,0.0008564793,0.0002825421,0.00007698459,0.00002212165,0.00006454671,0.0000359395,0.002227096],"genre_scores_gemma":[0.996379,0.001197421,0.000862537,0.0001572015,0.0001036265,0.00003320808,0.00007527907,0.00001322562,0.001178513],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001720418,"threshold_uncertainty_score":0.005755424,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03630092074123514,"score_gpt":0.307360648058503,"score_spread":0.2710597273172679,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}