{"id":"W2073537750","doi":"10.1038/nn.2941","title":"Pain sensitivity and vasopressin analgesia are mediated by a gene-sex-environment interaction","year":2011,"lang":"en","type":"article","venue":"Nature Neuroscience","topic":"Neuroendocrine regulation and behavior","field":"Psychology","cited_by":117,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University; McGill University Health Centre","funders":"National Center for Research Resources; National Institute of Neurological Disorders and Stroke; Georgia Clinical and Translational Science Alliance; National Institute on Drug Abuse; National Institute on Aging; National Institutes of Health; National Institute of Dental and Craniofacial Research; Louise and Alan Edwards Foundation","keywords":"Vasopressin; Desmopressin; Analgesic; Medicine; Neuropeptide; Capsaicin; Single-nucleotide polymorphism; Pharmacology; Neuroscience; Receptor; Psychology; Internal medicine; Gene; Biology; Genetics; Genotype","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002195252,0.0001365429,0.0001167941,0.00007769794,0.00009880563,0.00002796035,0.00009969779,0.00009137128,0.0001466926],"category_scores_gemma":[0.00009438951,0.0001212535,0.00003049211,0.0001585147,0.0001497019,0.0001071618,0.00005277086,0.0004289977,0.00002165677],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001684487,"about_ca_system_score_gemma":0.000005542936,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001961386,"about_ca_topic_score_gemma":0.000006117612,"domain_scores_codex":[0.9985399,0.0003695306,0.0001320196,0.0005079599,0.0002217154,0.0002288765],"domain_scores_gemma":[0.9994099,0.00009398077,0.0001140234,0.0002504509,0.00001454822,0.0001170894],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.000058906,0.0003950257,0.1321589,0.000005198787,0.000003295393,0.0004760962,0.000293053,0.000001953117,0.8446332,0.00008993788,0.01143659,0.01044784],"study_design_scores_gemma":[0.0002995778,0.0001150662,0.9366323,0.000006140342,0.0000145818,0.0002495738,0.00007453892,0.0004209855,0.03109775,0.00001237452,0.03090258,0.000174546],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9973339,0.0001207119,0.0003787909,0.0007313013,0.000709788,0.0001670635,0.00002363428,0.00006203863,0.0004727719],"genre_scores_gemma":[0.9965467,0.00001182706,0.00007081169,0.002187882,0.00003015775,0.00001105147,0.000004155325,0.00001079708,0.00112665],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.8135355,"threshold_uncertainty_score":0.4944575,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02848555821556393,"score_gpt":0.2945630465918869,"score_spread":0.2660774883763229,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}