{"id":"W2073548683","doi":"10.1371/journal.pone.0083145","title":"Polyoxygenated Cholesterol Ester Hydroperoxide Activates TLR4 and SYK Dependent Signaling in Macrophages","year":2013,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Cholesterol and Lipid Metabolism","field":"Medicine","cited_by":52,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba","funders":"National Institute of General Medical Sciences; National Heart, Lung, and Blood Institute; National Key Research and Development Program of China; National Natural Science Foundation of China; National Cancer Institute; National Institutes of Health; Pfizer","keywords":"Syk; Foam cell; TLR4; Macrophage; Chemistry; Cell biology; Inflammation; Intracellular; Cell signaling; Signal transduction; Biochemistry; Biology; Immunology; Tyrosine kinase","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001435373,0.0002723197,0.0002316467,0.0002763813,0.0001831438,0.0001727808,0.0001074042,0.0002746258,0.001313265],"category_scores_gemma":[0.00008771194,0.0001302974,0.0003650566,0.0001259326,0.0001552095,0.0001701988,0.0003208209,0.0004017429,0.000455495],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001930141,"about_ca_system_score_gemma":0.0002105843,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00018153,"about_ca_topic_score_gemma":0.0002417735,"domain_scores_codex":[0.9998504,0.00002850068,0.00001272209,0.00002120541,0.00003369611,0.00005343927],"domain_scores_gemma":[0.9999552,0.000005014803,0.00001479823,0.000004889333,0.000007831132,0.0000122236],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000454809,0.00005265834,0.0004691046,0.00007592432,0.00001054574,0.0001026633,0.00002200958,0.00004549071,0.9970162,0.00006473035,0.00007876493,0.001607058],"study_design_scores_gemma":[0.0001575421,0.0008744819,0.03261837,0.00002426831,0.00004991086,0.0005911383,0.000158245,0.002268021,0.9596291,0.0003315385,0.003284511,0.0000128978],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9948289,0.001748382,0.001510819,0.0002003031,0.00004418114,0.00003579242,0.0002676153,0.00003242482,0.001331551],"genre_scores_gemma":[0.993553,0.001508374,0.001454881,0.0001760225,0.00003227083,0.0001089192,0.0004847462,0.000007214818,0.002674663],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001313265,"threshold_uncertainty_score":0.004393339,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02652849036410738,"score_gpt":0.2178814269339673,"score_spread":0.19135293656986,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}