{"id":"W2073548683","doi":"10.1371/journal.pone.0083145","title":"Polyoxygenated Cholesterol Ester Hydroperoxide Activates TLR4 and SYK Dependent Signaling in Macrophages","year":2013,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Cholesterol and Lipid Metabolism","field":"Medicine","cited_by":52,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba","funders":"National Institute of General Medical Sciences; National Heart, Lung, and Blood Institute; National Key Research and Development Program of China; National Natural Science Foundation of China; National Cancer Institute; National Institutes of Health; Pfizer","keywords":"Syk; Foam cell; TLR4; Macrophage; Chemistry; Cell biology; Inflammation; Intracellular; Cell signaling; Signal transduction; Biochemistry; Biology; Immunology; Tyrosine kinase","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001383241,0.0002291079,0.0004882147,0.0001945599,0.0000457709,0.00008100439,0.00009355257,0.0001217822,0.0002806897],"category_scores_gemma":[0.00006487301,0.0001849018,0.00004112021,0.0001505323,0.00005810241,0.0002845711,0.00008792891,0.0003413713,0.0001880513],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004054892,"about_ca_system_score_gemma":0.00002198971,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003685859,"about_ca_topic_score_gemma":0.00002223069,"domain_scores_codex":[0.9984992,0.00006214561,0.0003398367,0.0003735521,0.0003438734,0.0003814371],"domain_scores_gemma":[0.9992828,0.0000537657,0.00007283335,0.000287121,0.00007314835,0.0002303513],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006560789,0.0008387367,0.04816134,0.0001694823,0.0001334989,0.00002423542,0.000457086,0.000002954606,0.9471394,0.000003282124,0.00001565594,0.002988669],"study_design_scores_gemma":[0.002839979,0.0001222616,0.400129,0.000625946,0.000153198,0.00002911677,0.000145667,0.0002961782,0.5953606,0.00003616638,0.00005639287,0.00020552],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.996507,0.0008565596,0.000005103823,0.001419921,0.00004224448,0.0006789317,0.000003968707,0.00008013276,0.0004061628],"genre_scores_gemma":[0.9958977,0.000167136,0.0005486824,0.001259925,0.0002302609,0.0000821582,0.00001064075,0.00004671876,0.00175685],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3519677,"threshold_uncertainty_score":0.7540075,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02652849036410738,"score_gpt":0.2178814269339673,"score_spread":0.19135293656986,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}