{"id":"W2073581978","doi":"10.1073/pnas.1005997107","title":"Fas-associated death domain (FADD) is a negative regulator of T-cell receptor–mediated necroptosis","year":2010,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Cell death mechanisms and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":153,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network; Ontario Institute for Cancer Research","funders":"National Institutes of Health","keywords":"FADD; Necroptosis; Programmed cell death; Death domain; Cell biology; RIPK1; Biology; Caspase 8; T-cell receptor; T cell; Apoptosis; Cancer research; Caspase; Immunology; Immune system; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007785664,0.0001001452,0.0001438052,0.00008171661,0.0001248096,0.0000103572,0.0004547112,0.000215132,0.00002948429],"category_scores_gemma":[0.0003743821,0.00006976294,0.0001049759,0.0004028673,0.0004505705,0.00001957426,0.0001218968,0.0001214041,7.107878e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001087461,"about_ca_system_score_gemma":0.00004754622,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000009352325,"about_ca_topic_score_gemma":3.371565e-7,"domain_scores_codex":[0.9987119,0.000008107942,0.0002959813,0.0002377868,0.0006125276,0.0001337315],"domain_scores_gemma":[0.9989157,0.00003519255,0.0005771873,0.00001486404,0.000420481,0.00003659302],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001972694,0.00005952722,0.002270425,0.00001915801,0.00001845049,7.754716e-10,0.0001290307,0.000005413049,0.9921786,0.004750496,0.0004612554,0.00008792798],"study_design_scores_gemma":[0.0002835886,0.00009216461,0.01921339,0.00002732839,0.000009597944,8.853684e-7,0.0001115166,0.0001858953,0.9679356,0.01162596,0.0004345347,0.00007952212],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9968224,0.00004325153,0.000002702238,0.0006073832,0.00003466847,0.0001617875,0.00004836574,0.000004084694,0.002275419],"genre_scores_gemma":[0.9960865,0.00004462534,0.003327986,0.0001170767,0.00005728824,0.000006108512,0.000002381674,0.000005831074,0.0003522067],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02424297,"threshold_uncertainty_score":0.284485,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01525735688727316,"score_gpt":0.2595075731037716,"score_spread":0.2442502162164984,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}