{"id":"W2073582856","doi":"10.1038/sj.clpt.6100246","title":"Identification of Novel CYP2A6*1B Variants: The CYP2A6*1B Allele is Associated With Faster In Vivo Nicotine Metabolism","year":2007,"lang":"en","type":"article","venue":"Clinical Pharmacology & Therapeutics","topic":"Pharmacogenetics and Drug Metabolism","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":64,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre for Addiction and Mental Health; University of Toronto","funders":"Canadian Institutes of Health Research; NIH Clinical Center; National Institutes of Health; National Center for Research Resources; National Institute on Drug Abuse; Canada Research Chairs","keywords":"CYP2A6; Nicotine; Cotinine; In vivo; Genotype; Pharmacology; Metabolism; Chemistry; Biology; Medicine; Endocrinology; Internal medicine; Genetics; Cytochrome P450; Biochemistry; CYP1A2; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.008779608,0.0006723023,0.001225002,0.0003288573,0.0003444805,0.00003658741,0.001382727,0.0009455581,0.001481556],"category_scores_gemma":[0.0001335111,0.0005111289,0.0004147716,0.001130459,0.001541487,0.0002007206,0.0002927219,0.002674763,0.00007389663],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009890784,"about_ca_system_score_gemma":0.0003039998,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001802689,"about_ca_topic_score_gemma":0.00006323908,"domain_scores_codex":[0.9926415,0.001705873,0.002820145,0.0009554085,0.0005615783,0.001315511],"domain_scores_gemma":[0.9933987,0.003445771,0.001455685,0.0006427702,0.0006277378,0.0004293518],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.004420639,0.01439837,0.0230896,0.00005446566,0.005797454,0.00008235376,0.003089425,0.001073186,0.9238968,0.0004815597,0.01233258,0.0112835],"study_design_scores_gemma":[0.03740682,0.0005441522,0.07168546,0.00003836464,0.006738788,0.00005356417,0.0005061927,0.02007647,0.4807601,0.0004978974,0.3804256,0.001266553],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9791145,0.002989065,0.002152216,0.007255483,0.00528568,0.001473761,0.0003696068,0.0001132887,0.001246389],"genre_scores_gemma":[0.9155599,0.002882228,0.0002295197,0.07907721,0.0009663044,0.00007851549,0.0000353898,0.0001075499,0.001063373],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4431368,"threshold_uncertainty_score":0.999734,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1744693395500832,"score_gpt":0.4823130279593351,"score_spread":0.3078436884092519,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}