{"id":"W2073651499","doi":"10.1097/cji.0b013e3181a6981c","title":"Engineering and Biological Characterization of VB6-845, an Anti-EpCAM Immunotoxin Containing a T-cell Epitope-depleted Variant of the Plant Toxin Bouganin","year":2009,"lang":"en","type":"article","venue":"Journal of Immunotherapy","topic":"Toxin Mechanisms and Immunotoxins","field":"Immunology and Microbiology","cited_by":79,"is_retracted":false,"has_abstract":true,"ca_institutions":"Viventia Bio (Canada)","funders":"","keywords":"Immunotoxin; Epitope; Epithelial cell adhesion molecule; In vitro; Linker; Chemistry; Molecular biology; Fusion protein; Furin; Moiety; Recombinant DNA; In vivo; Biology; Cell; Biochemistry; Antigen; Gene; Cytotoxicity; Stereochemistry; Immunology; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007883935,0.0002576302,0.000708822,0.0001769439,0.0001386472,0.00002959099,0.0004979582,0.0002999408,0.0001373354],"category_scores_gemma":[0.00007653607,0.0001717106,0.0002101476,0.0001968788,0.0001525976,0.0002287232,0.00003755124,0.0004733482,0.000002143225],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002727416,"about_ca_system_score_gemma":0.0001108298,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001299157,"about_ca_topic_score_gemma":4.830289e-7,"domain_scores_codex":[0.9980921,0.000290197,0.001043809,0.0001838068,0.00008480139,0.000305258],"domain_scores_gemma":[0.9982315,0.0001065242,0.001129807,0.000352542,0.000151208,0.00002844877],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006158401,0.0002853422,0.0007020964,0.0000109067,0.0001616831,0.000007787365,0.001625511,0.00001710237,0.9913006,0.0006425083,0.000006785315,0.004623791],"study_design_scores_gemma":[0.003337269,0.002576391,0.102072,0.0002493077,0.00002899197,0.0004170927,0.0003529967,0.000047381,0.8892292,0.0001001383,0.001380556,0.0002086065],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9924579,0.004521916,0.001865154,0.0001208678,0.0006924075,0.0002586664,0.00004888317,0.00001692485,0.00001731082],"genre_scores_gemma":[0.9978759,0.001367156,0.000489536,0.0001422096,0.00004346372,0.00000229419,0.00001905785,0.00002369348,0.00003666514],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1020714,"threshold_uncertainty_score":0.7002155,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01039473604032971,"score_gpt":0.2045307355427179,"score_spread":0.1941359995023882,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}