{"id":"W2073651499","doi":"10.1097/cji.0b013e3181a6981c","title":"Engineering and Biological Characterization of VB6-845, an Anti-EpCAM Immunotoxin Containing a T-cell Epitope-depleted Variant of the Plant Toxin Bouganin","year":2009,"lang":"en","type":"article","venue":"Journal of Immunotherapy","topic":"Toxin Mechanisms and Immunotoxins","field":"Immunology and Microbiology","cited_by":79,"is_retracted":false,"has_abstract":true,"ca_institutions":"Viventia Bio (Canada)","funders":"","keywords":"Immunotoxin; Epitope; Epithelial cell adhesion molecule; In vitro; Linker; Chemistry; Molecular biology; Fusion protein; Furin; Moiety; Recombinant DNA; In vivo; Biology; Cell; Biochemistry; Antigen; Gene; Cytotoxicity; Stereochemistry; Immunology; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000162674,0.000206368,0.0001524428,0.0001692272,0.0001216094,0.0002477846,0.0001981001,0.0002547282,0.0003006083],"category_scores_gemma":[0.0001423826,0.00009198327,0.0001729208,0.0001571765,0.0001704905,0.0001418486,0.00013804,0.0003755324,0.0001800671],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004304785,"about_ca_system_score_gemma":0.000150506,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001365558,"about_ca_topic_score_gemma":0.001037276,"domain_scores_codex":[0.9998966,0.00001467139,0.000008710043,0.0000200274,0.00003908804,0.00002088634],"domain_scores_gemma":[0.9999255,0.000009456387,0.0000257232,0.000006970734,0.00001310224,0.00001918303],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001237501,0.00001008227,0.0000653362,0.000009387112,0.000001105656,0.00001823309,0.00000614678,0.000113757,0.999431,0.00003729869,0.000005592529,0.0002897052],"study_design_scores_gemma":[0.00000867746,0.000296146,0.002809401,0.000004177212,0.000009579979,0.000212507,0.00001680846,0.001086161,0.9933785,0.00001749381,0.002157245,0.000003402394],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9943674,0.0004144497,0.004322954,0.00004257184,0.000007888189,0.00003925534,0.0002065707,0.00001622727,0.0005824676],"genre_scores_gemma":[0.9910597,0.0003375316,0.005881457,0.00003777563,0.000003674101,0.00002075073,0.0009678298,0.0000132673,0.001678008],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001365558,"threshold_uncertainty_score":0.003123343,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01039473604032971,"score_gpt":0.2045307355427179,"score_spread":0.1941359995023882,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}