{"id":"W2073691872","doi":"10.1016/s0735-1097(15)60258-3","title":"RVX-208 THE FIRST SELECTIVE BROMODOMAIN EXTRA-TERMINAL PROTEIN INHIBITOR BEING DEVELOPED FOR PATIENTS WITH HIGH RESIDUAL RISKS OF CARDIOVASCULAR DISEASE","year":2015,"lang":"en","type":"article","venue":"Journal of the American College of Cardiology","topic":"Cardiovascular Disease and Adiposity","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Resverlogix (Canada)","funders":"","keywords":"Medicine; Bromodomain; Disease; Terminal (telecommunication); Cardiology; Internal medicine; Pharmacology; Genetics; Gene; Epigenetics; Computer network","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002359254,0.0002978738,0.0008214089,0.0001562625,0.0001603107,0.0003866,0.0002449751,0.0003430162,0.001608701],"category_scores_gemma":[0.000229109,0.00009253304,0.0003223059,0.0001258539,0.0001864868,0.0001587048,0.0001755093,0.001195264,0.000605933],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002695619,"about_ca_system_score_gemma":0.0004116714,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002568739,"about_ca_topic_score_gemma":0.0008576616,"domain_scores_codex":[0.9999318,0.00001369003,0.000005333713,0.00001033948,0.00001505132,0.00002373284],"domain_scores_gemma":[0.9999108,0.000020053,0.00001959671,0.000005247442,0.000008902625,0.00003534578],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.01502287,0.00126516,0.01199489,0.001175263,0.000625389,0.002526753,0.0001235445,0.00110404,0.2644647,0.003124368,0.01489913,0.683674],"study_design_scores_gemma":[0.02586159,0.08010828,0.1372619,0.0006969906,0.001934927,0.0389703,0.0002512237,0.005468113,0.3297911,0.001991265,0.3774152,0.0002490809],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.884708,0.07540629,0.006085692,0.002673451,0.001064212,0.0002948573,0.001391319,0.0006625972,0.02771357],"genre_scores_gemma":[0.9620937,0.01890449,0.004871223,0.002012619,0.0002914006,0.0001259519,0.001705802,0.00004593108,0.009948944],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001608701,"threshold_uncertainty_score":0.005381644,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02072582531308351,"score_gpt":0.2563658075712952,"score_spread":0.2356399822582117,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}