{"id":"W2073695749","doi":"10.1074/jbc.m106306200","title":"Substrate Specificity of the Streptococcal Cysteine Protease","year":2001,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Streptococcal Infections and Treatments","field":"Medicine","cited_by":31,"is_retracted":false,"has_abstract":true,"ca_institutions":"Biotechnology Research Institute","funders":"","keywords":"Scissile bond; Chemistry; Stereochemistry; Endopeptidase; Cysteine; Zymogen; Papain; Active site; Enzyme kinetics; Protease; Cysteine protease; Substrate (aquarium); Oxyanion hole; Enzyme; Biochemistry; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003382647,0.000377501,0.0003463888,0.0001164125,0.0001103555,0.0004944571,0.0002132079,0.0003546888,0.0008195884],"category_scores_gemma":[0.0005057361,0.0001450472,0.0001969368,0.000191306,0.0001339733,0.0002137758,0.0002285548,0.0003908834,0.0005897628],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003312581,"about_ca_system_score_gemma":0.0001958175,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002526953,"about_ca_topic_score_gemma":0.0002632712,"domain_scores_codex":[0.9993655,0.0001727823,0.00006397243,0.0001523879,0.000177095,0.00006825376],"domain_scores_gemma":[0.9996965,0.0000908229,0.00005693925,0.0000414721,0.00007125033,0.00004296406],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006779768,0.000008687575,0.0003126716,0.00005185929,0.000004264407,0.00004052552,0.00000820865,0.00008552916,0.9969656,0.0000938874,0.00003521661,0.002325797],"study_design_scores_gemma":[0.000003959857,0.0001015958,0.001678228,0.00000558991,0.00000531796,0.0004043058,0.000007910608,0.0006003839,0.9956549,0.00003587195,0.001497224,0.000004673646],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9752709,0.00801049,0.01220634,0.0001238604,0.00004289548,0.00005313095,0.0004120256,0.0001352001,0.00374522],"genre_scores_gemma":[0.9882783,0.001729067,0.00756992,0.0000707392,0.000009549136,0.0000345751,0.0006362007,0.00002696564,0.001644752],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008195884,"threshold_uncertainty_score":0.002741814,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04299199693090495,"score_gpt":0.2905725375935582,"score_spread":0.2475805406626532,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}