{"id":"W2073702274","doi":"10.1006/bbrc.2000.3960","title":"Roles of Agonist-Binding Sites in Nicotinic Acetylcholine Receptor Function","year":2000,"lang":"en","type":"article","venue":"Biochemical and Biophysical Research Communications","topic":"Nicotinic Acetylcholine Receptors Study","field":"Biochemistry, Genetics and Molecular Biology","cited_by":9,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta","funders":"Medical Research Council","keywords":"Agonist; Chemistry; Alpha-4 beta-2 nicotinic receptor; Acetylcholine receptor; Receptor; Biophysics; Nicotinic acetylcholine receptor; Torpedo; Nicotinic agonist; Binding site; Acetylcholine; Desensitization (medicine); Partial agonist; Muscarinic acetylcholine receptor M5; Biochemistry; Muscarinic acetylcholine receptor M3; Endocrinology; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006247706,0.0001538207,0.000228155,0.00009228115,0.0001686902,0.00002626451,0.0006867751,0.000190479,0.0001129528],"category_scores_gemma":[0.0004032648,0.000139799,0.00009429541,0.000521173,0.0008077088,0.00000982289,0.0005232827,0.000479818,0.00006196155],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002845319,"about_ca_system_score_gemma":0.00007922042,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003850841,"about_ca_topic_score_gemma":0.0000526254,"domain_scores_codex":[0.9982443,0.0003083099,0.0003738391,0.0003995057,0.0003006152,0.0003734398],"domain_scores_gemma":[0.9984351,0.0001959158,0.00005682458,0.0009925284,0.0001766616,0.0001429084],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001764037,0.0006347109,0.001535619,0.00001936305,0.00002604638,3.259098e-8,0.00004743721,6.814096e-7,0.9861578,0.0002822362,0.002097921,0.009021698],"study_design_scores_gemma":[0.001006747,0.0005505451,0.002021376,0.00007705726,0.00001765394,0.000002337229,0.0002579663,0.0002207531,0.9467795,0.0002007353,0.04859595,0.0002693798],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9953265,0.001767542,0.00000825154,0.001152561,0.00001447622,0.0002671917,0.00004455945,0.00001347664,0.001405406],"genre_scores_gemma":[0.9929076,0.004785728,0.0009123408,0.00003903313,0.0001453729,0.00006115001,0.0003763595,0.00001927457,0.0007530781],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04649803,"threshold_uncertainty_score":0.5700837,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0485671255041145,"score_gpt":0.3602684342526306,"score_spread":0.3117013087485161,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}